ArticleNeuroscience2013
Central PACAP mediates the sympathetic effects of leptin in a tissue-specific manner.
Article in Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Ventromedial hypothalamic nucleus subset stimulates tissue thermogenesis via preoptic area outputs.Molecular metabolism · 2024Article
- PACAP and VIP Neuropeptides' and Receptors' Effects on Appetite, Satiety and Metabolism.Biology · 2023Review
- Impact of Vitamin D Supplementation on Inflammatory Markers' Levels in Obese Patients.Current issues in molecular biology · 2021Article
- The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism.Endocrinology · 2021Article
- Adaptive Changes in the Central Control of Energy Homeostasis Occur in Response to Variations in Energy Status.International journal of molecular sciences · 2021Review
- Electroconvulsive seizures lead to lipolytic-induced gene expression changes in mediobasal hypothalamus and decreased white adipose tissue mass.Neuropsychopharmacology reports · 2021Article
- PACAP: A regulator of mammalian reproductive function.Molecular and cellular endocrinology · 2020Review
- Effects of Feeding-Related Peptides on Neuronal Oscillation in the Ventromedial Hypothalamus.Journal of clinical medicine · 2019Article
- PACAP neurons in the ventral premammillary nucleus regulate reproductive function in the female mouse.eLife · 2018Article
- Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization.American journal of physiology. Heart and circulatory physiology · 2017Review
- Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by Sustained Renal Sympathoexcitation.Frontiers in physiology · 2017Article
- Mechanistic relationship between the vagal afferent pathway, central nervous system and peripheral organs in appetite regulation.Journal of diabetes investigation · 2016Review
- PACAP intraperitoneal treatment suppresses appetite and food intake via PAC1 receptor in mice by inhibiting ghrelin and increasing GLP-1 and leptin.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Origins and neurochemical complexity of preganglionic neurons supplying the superior cervical ganglion in the domestic pig.Journal of molecular neuroscience : MN · 2015Article
- Resistin, an Adipokine with Non-Generalized Actions on Sympathetic Nerve Activity.Frontiers in physiology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
We previously demonstrated that the peptidergic neurotransmitter pituitary adenylate cyclase-activating polypeptide (PACAP) affects the autonomic system and contributes to the control of metabolic and cardiovascular functions. Previous studies have demonstrated the importance of centrally-mediated sympathetic effects of leptin for obesity-related hypertension. Here we tested whether PACAP signaling in the brain is implicated in leptin-induced sympathetic excitation and appetite suppression. In anesthetized mice, intracerebroventricular (ICV) pre-treatment with PACAP6-38, an antagonist of the PACAP receptors (PAC1-R and VPAC2), inhibited the increase in white adipose tissue sympathetic nerve activity (WAT-SNA) produced by ICV leptin (2μg). In contrast, leptin-induced stimulation of renal sympathetic nerve activity (RSNA) was not affected by ICV pre-treatment with PACAP6-38. Moreover, in PACAP-deficient (Adcyap1-/-) mice, ICV leptin-induced WAT-SNA increase was impaired, whereas RSNA response was preserved. The reductions in food intake and body weight evoked by ICV leptin were attenuated in Adcyap1-/- mice. Our data suggest that hypothalamic PACAP signaling plays a key role in the control by leptin of feeding behavior and lipocatabolic sympathetic outflow, but spares the renal sympathetic traffic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.