ArticleHeart rhythm2013
Acute regional left atrial ischemia causes acceleration of atrial drivers during atrial fibrillation.
Article in Heart rhythm, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Outcomes and Management of Stressor-Associated Atrial Fibrillation: JACC State-of-the-Art Review.Journal of the American College of Cardiology · 2025Review
- Insulin mitigates acute ischemia-induced atrial fibrillation and sinoatrial node dysfunction ex vivo.JCI insight · 2024Article
- Attenuating persistent sodium current-induced atrial myopathy and fibrillation by preventing mitochondrial oxidative stress.JCI insight · 2021Article
- Theoretical Models and Computational Analysis of Action Potential Dispersion for Cardiac Arrhythmia Risk Stratification.Frontiers in cardiovascular medicine · 2021Article
- Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels.JCI insight · 2020Article
- Cardiac arrhythmias in patients with COVID-19.Journal of arrhythmia · 2020Review
- Dietary Saturated Fat Promotes Arrhythmia by Activating NOX2 (NADPH Oxidase 2).Circulation. Arrhythmia and electrophysiology · 2019Article
- Heterogeneity of the action potential duration is required for sustained atrial fibrillation.JCI insight · 2019Article
- Association of of Atrial Fibrillation Clinical Phenotypes With Treatment Patterns and Outcomes: A Multicenter Registry Study.JAMA cardiology · 2018Article
- Electrochemical degradation of trichloroethylene in aqueous solution by bipolar graphite electrodes.Journal of environmental chemical engineering · 2016Article
- Digital resolution enhancement of intracardiac excitation maps during atrial fibrillation.Journal of clinical monitoring and computing · 2015Article
- Cardiac Events Theoretically Cannot Be Produced By Non-Ischemic And/Or Iso-Ischemic Myocardium: Challenging Postulations And Vitality Of The Concept Of "Ischemia-Dependent Conflictogenic Arrhythmias".Journal of atrial fibrillation · 2013Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe mechanisms by which acute left atrial ischemia (LAI) leads to atrial fibrillation (AF) initiation and perpetuation remain unclear.
objectiveTo investigate the electrophysiological mechanisms of AF perpetuation in the presence of regional atrial ischemia.
methodsLAI (90-minute ischemia) was obtained in isolated sheep hearts by selectively perfusing microspheres into the left anterior atrial artery. Two charge-coupled device cameras and several bipolar electrodes enabled recording from multiple atrial locations: with a dual-camera setup (protocol 1, n = 10, and protocol 1', n = 4, for biatrial or atrioventricular camera setups, respectively), in the presence of propranolol/atropine (1 μM) added to the perfusate after LAI (protocol 2, n = 3) and after a pretreatment with glibenclamide (10 μM; protocol 3, n = 4).
resultsSpontaneous AF occurred in 41.2% (7 of 17) of the hearts that were in sinus rhythm before LAI. LAI caused action potential duration shortening in both the ischemic (IZ) and nonischemic (NIZ) zones by 21% ± 8% and 34% ± 13%, respectively (pacing, 5 Hz; P<.05 compared to baseline). Apparent impulse velocity was significantly reduced in the IZ but not in the NIZ (-65% ± 19% and 9% ± 18%; P = .001 and NS, respectively). During LAI-related AF, a significant NIZ maximal dominant frequency increase from 7.4 ± 2.5 to 14.0 ± 5.5 Hz (P<.05) was observed. Glibenclamide, an ATP-sensitive potassium current (IKATP) channel blocker, averted LAI-related maximal dominant frequency increase (NIZ: LAI vs glibenclamide 14.0 ± 5.5 Hz vs 5.9 ± 1.3 Hz; P<.05). An interplay between spontaneous focal discharges and rotors, locating at the IZ-NIZ border zone, maintained LAI-related AF.
conclusionsLAI leads to an IKATP conductance-dependent action potential duration shortening and spontaneous AF maintained by both spontaneous focal discharges and reentrant circuits locating at the IZ border zone.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.