Evidence map›Paper›PMID 23454290›Full record

ReviewMethods (San Diego, Calif.)2013

Quantification of histone modifications using ¹⁵N metabolic labeling.

Chunchao Zhang, Yifan Liu, Philip C Andrews

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methods (San Diego, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chunchao ZhangDepartment of Computational Medicine and Bioinformatics, University of Michigan, USA.
Yifan Liu
Philip C Andrews

Funding

UNDERSTANDING THE PATHOGENESIS OF CAMPYLOBACTER JEJUNIP41RR018627 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FINLEY, RUSSELL L · 2003 to 2007
$12.4M
Polycomb-mediated heterochromatin formation in TetrahymenaR01GM087343 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIU, YIFAN · 2010 to 2014
$1.4M
NCRR NIH HHS 1P41RR018627NCRR NIH HHS P41 RR018627NIGMS NIH HHS R01 GM087343NIGMS NIH HHS R01GM087343
6 · The paper itself

Abstract

Mass spectrometry has made major contributions to recent discoveries in the field of epigenetics, particularly in the characterization of the myriad post-translational modifications (PTMs) of histones which are technically challenging to analyze. These new developments have further aroused great interest in development of robust, new mass spectrometric methods to quantitatively study the dynamics of histone modifications. This review covers quantitative analysis of histone PTMs and discuss an ¹⁵N metabolic labeling procedure for quantifying histone PTMs applied to the analysis of methyltransferase knockouts in the model organism, Tetrahymena thermophila.

Indexed as

Protein Processing, Post-TranslationalAcetylationAmino Acid SequenceEscherichia coliGene ExpressionHistonesHumansIsotope LabelingMass SpectrometryMethylationMolecular Sequence DataNitrogen IsotopesPeptidesRecombinant ProteinsTetrahymena thermophilaHistonesNitrogen IsotopesPeptidesRecombinant Proteins

Identifiers

PMID23454290
PMCPMC3700598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.