ArticleNeuroscience letters2013
Increased error-related brain activity in youth with obsessive-compulsive disorder and other anxiety disorders.
Article in Neuroscience letters, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Event-related potential in juvenile obsessive-compulsive disorder: a systematic review and meta-analysis of error- and correct-related negativity.European child & adolescent psychiatry · 2025Pooled it
- Age-related differences in the error-related negativity and error positivity in children and adolescents are moderated by sample and methodological characteristics: A meta-analysis.Psychophysiology · 2022Pooled it
- The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review.BMC psychiatry · 2016Pooled it
- Error-related brain activity in pediatric anxiety disorders remains elevated following individual therapy: a randomized clinical trial.Journal of child psychology and psychiatry, and allied disciplines · 2018Trial
- Electrophysiological Correlates of Cognitive Dysfunction in Obsessive-Compulsive Disorder (OCD): A Systematic and Mechanistic Review of EEG, ERP, and QEEG Evidence.Journal of clinical medicine · 2026Review
- Error-Related Brain Potentials as Biomarkers of Pathology Severity and Treatment Resistance in Patients With Obsessive-Compulsive Disorder.Depression and anxiety · 2026Article
- The Impact of Test Anxiety and Cognitive Stress on Error-Related Brain Activity.Behavioral sciences (Basel, Switzerland) · 2025Article
- Altered Reward Processing in Obsessive-Compulsive Disorder: Insights From Active and Observational Learning.Psychophysiology · 2025Article
- Threats That Arise From Within: Changes in Error Processing and the Prospective Prediction of Everyday Avoidance.Biological psychiatry global open science · 2025Article
- Emotion Regulation Moderates the Prospective Association between ERN and Anxiety in Early Adolescence: An Age-Specific Moderation of Cognitive Reappraisal but not Expressive Suppression.Research on child and adolescent psychopathology · 2025Article
- Enhanced Performance Monitoring as a Transdiagnostic Risk Marker of the Anxiety and Obsessive-Compulsive Spectrum: The Role of Disorder Category, Clinical Status, Family Risk, and Anxiety Dimensions.Depression and anxiety · 2025Article
- Stimulus-related oscillatory brain activity discriminates hoarding disorder from OCD and healthy controls.Biological psychology · 2024Article
- Flanker task parameters are related to the strength of association between the ERN and anxiety: a meta-analysis.bioRxiv : the preprint server for biology · 2024Article
- Error-related brain activity associated with obsessive-compulsive symptoms in youth.Brain and behavior · 2023Article
- Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders.Molecular neurobiology · 2023Review
- Post-error slowing in anxiety and obsessive-compulsive disorders.Cognitive, affective & behavioral neuroscience · 2022Article
- Age-related qualitative differences in post-error cognitive control adjustments.The British journal of developmental psychology · 2022Article
- Spatial attention impairments are characterized by specific electro-encephalographic correlates and partially mediate the association between early life stress and anxiety.Cognitive, affective & behavioral neuroscience · 2022Article
- What Event-Related Potential Tells Us about Brain Function: Child-Adolescent Psychiatric Perspectives.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2021Review
- A dimensional investigation of error-related negativity (ERN) and self-reported psychiatric symptoms.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response that is thought to reflect activity in the anterior cingulate cortex (ACC) and is often increased in patients with anxiety disorders. This study measured the ERN and correct response negativity (CRN) during an Eriksen flanker task to assess performance monitoring in 26 youth with obsessive-compulsive disorder (OCD), 13 youth with a non-OCD anxiety disorder consisting of either generalized anxiety disorder or separation anxiety disorder, and 27 age-matched healthy controls ranging in age from 8 to 16 years. Compared to healthy controls, ERN amplitude was significantly increased in patients with either OCD or a non-OCD anxiety disorder. There were no significant group differences in CRN amplitude. Treatment with a serotonergic antidepressant or cognitive-behavior therapy had no effect on the ERN in patients. Scores from the Child Behavior Checklist DSM-oriented anxiety problems scale had a significant correlation with ERN amplitude in all subjects. The results provide further evidence that the pathophysiology of OCD and some non-OCD anxiety disorders involves increased ACC activity and that the ERN may serve as a quantitative phenotype in genetic and longitudinal studies of these complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.