Evidence map›Paper›PMID 23454257›Full record

ArticleResuscitation2013

Survival in out-of-hospital cardiac arrests with initial asystole or pulseless electrical activity and subsequent shockable rhythms.

Andrew J Thomas, Craig D Newgard, Rongwei Fu, Dana M Zive, Mohamud R Daya

Abstract read
In one paragraph

Article in Resuscitation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Aminophylline for bradyasystolic cardiac arrest in adults.The Cochrane database of systematic reviews · 2015
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrew J ThomasDepartment of Public Health & Preventive Medicine, Oregon Health & Science University, Portland, OR 97239, USA. thomandr@ohsu.edu
Craig D Newgard
Rongwei Fu
Dana M Zive
Mohamud R Daya

Funding

Resuscitation Outcomes Consortium (ROC) Data Coordinating CenterU01HL077863 · NHLBI · UNIVERSITY OF WASHINGTON · PI MAY, SUSANNE · 2004 to 2015
$125.1M
Oregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-PittsburghU01HL077871 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALLAWAY, CLIFTON W. · 2004 to 2015
$4.0M
Southeastern Resucitation Research CenterU01HL077881 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KERBY, JEFFREY D, WANG, HENRY E. · 2004 to 2015
$3.9M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-PortlandU01HL077873 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAYA, MOHAMUD RAMZANALI · 2004 to 2015
$3.9M
Resuscitation Outcomes Consortium Regional Clinical Center-DFW Center for ResusciU01HL077887 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI IDRIS, AHAMED H · 2004 to 2015
$3.2M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Centers-MilwaukeeU01HL077866 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI AUFDERHEIDE, TOM PAUL · 2004 to 2015
$3.0M
Resuscitation Outcomes Consortium (ROC) Regional Clinical Center-OTTAWA-OPALS-BCRU01HL077885 · NHLBI · OTTAWA HOSPITAL RESEARCH INSTITUTE · PI STIELL, IAN G. · 2004 to 2015
$2.4M
The Iowa Resuscitation Network:A Rural Regional Clin CtrU01HL077865 · NHLBI · UNIVERSITY OF IOWA · PI KERBER, RICHARD E · 2004 to 2007
$1.7M
CIHRNCATS NIH HHS UL1 TR000128NHLBI NIH HHS 5U01 HL077863NHLBI NIH HHS HL077865NHLBI NIH HHS HL077866NHLBI NIH HHS HL077871NHLBI NIH HHS HL077873NHLBI NIH HHS HL077881NHLBI NIH HHS HL077885NHLBI NIH HHS HL077887NHLBI NIH HHS U01 HL077863NHLBI NIH HHS U01 HL077865NHLBI NIH HHS U01 HL077866NHLBI NIH HHS U01 HL077871NHLBI NIH HHS U01 HL077873NHLBI NIH HHS U01 HL077881NHLBI NIH HHS U01 HL077885NHLBI NIH HHS U01 HL077887
6 · The paper itself

Abstract

backgroundNon-shockable arrest rhythms (pulseless electrical activity and asystole) represent an increasing proportion of reported cases of out-of-hospital cardiac arrest (OHCA). The prognostic significance of conversion from non-shockable to shockable rhythms during the course of resuscitation remains unclear.

objectiveTo evaluate whether out-of-hospital cardiac arrest survival with initially non-shockable arrest rhythms is improved with subsequent conversion to shockable rhythms.

methodsSecondary analysis of data in Epistry - Cardiac Arrest, an epidemiologic registry maintained by the Resuscitation Outcomes Consortium (ROC). This analysis includes OHCA events from December 1, 2005 through May 31, 2007 contributed by six US and two Canadian sites. For all EMS-treated adult (18 and older) cardiac arrest patients who presented with non-shockable cardiac arrest, we compared survival to hospital discharge between patients who did develop a shockable rhythm and those who did not based on receipt of subsequent defibrillation. Missing data were handled using multiple imputation. Multivariable logistic regression was used to adjust for potentially confounding variables.

resultsA total of 6556 EMS treated adult cardiac arrest cases presented in non-shockable rhythms. Survival to discharge in patients who converted to a shockable rhythm was 2.77% while survival in those who did not was 2.72% (p=0.92). After adjusting for confounders, conversion to a shockable rhythm was not associated with improved survival (OR 0.88, 95% CI: 0.60-1.30).

conclusionFor OHCA patients presenting in PEA/asystole, survival to hospital discharge was not associated with conversion to a shockable rhythm during EMS resuscitation efforts.

Indexed as

AdultAgedAged, 80 and overCanadaCardiopulmonary ResuscitationCohort StudiesElectric CountershockElectrodiagnosisEmergency Medical ServicesFemaleHeart RateHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisCardiac arrestNon-shockable rhythmsOut-of-hospitalSurvival

Identifiers

PMID23454257
PMCPMC3947599

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.