ArticleRespiratory physiology & neurobiology2013
Serotonergic mechanisms are necessary for central respiratory chemoresponsiveness in situ.
Article in Respiratory physiology & neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Maximal strength and voluntary activation of adductor pollicis after a single session of acute intermittent hypercapnia or acute intermittent hypoxia.Experimental physiology · 2026Article
- Impact of Serotonergic 5HTInternational journal of molecular sciences · 2024Article
- Revisiting the Role of Serotonin in Sleep-Disordered Breathing.International journal of molecular sciences · 2024Review
- Whole-brain analysis of CObioRxiv : the preprint server for biology · 2023Article
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.Journal of neuropathology and experimental neurology · 2023Article
- Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups.Frontiers in physiology · 2023Review
- The retrotrapezoid nucleus and the neuromodulation of breathing.Journal of neurophysiology · 2021Review
- Baseline Arterial COFrontiers in physiology · 2021Article
- Differential modulation of active expiration during hypercapnia by the medullary raphe in unanesthetized rats.Pflugers Archiv : European journal of physiology · 2020Article
- Palliative Care in Heart Failure.Current treatment options in cardiovascular medicine · 2018Review
- Coordinated Respiratory Motor Activity in Nerves Innervating the Upper Airway Muscles in Rats.PloS one · 2016Article
- Isoflurane causes concentration-dependent inhibition of medullary raphé 5-HT neurons in situ.Autonomic neuroscience : basic & clinical · 2015Article
- The Alteration of Neonatal Raphe Neurons by Prenatal-Perinatal Nicotine. Meaning for Sudden Infant Death Syndrome.American journal of respiratory cell and molecular biology · 2015Article
- Functional link between the hypocretin and serotonin systems in the neural control of breathing and central chemosensitivity.Journal of neurophysiology · 2015Article
- Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- CO2-inhibited neurons in the medullary raphé are GABAergic.Respiratory physiology & neurobiology · 2014Article
- The Deakin/Graeff hypothesis: focus on serotonergic inhibition of panic.Neuroscience and biobehavioral reviews · 2014Review
- Intermittent hypercapnia enhances CO₂ responsiveness and overcomes serotonergic dysfunction.Respiratory physiology & neurobiology · 2014Article
- A group of non-serotonergic cells is CO2-stimulated in the medullary raphé.Neuroscience · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Evidence from in vivo and in vitro experiments conclude that serotonin (5-HT) neurons are involved in and play an important role in central respiratory CO2/H(+) chemosensitivity. This study was designed to assess the importance of 5-HT neurons and 5-HT receptor activation in the frequency and amplitude components of the hypercapnic response of the respiratory network in the unanesthetized perfused in situ juvenile rat brainstem preparation that exhibits patterns of phrenic nerve discharge similar to breathing in vivo. Exposure to a hypercapnic perfusate increased phrenic burst frequency and/or amplitude, the neural correlates of breathing frequency and tidal volume in vivo. Hypercapnic responses were also assessed during exposure to ketanserin (5-HT2 receptor antagonist), and 8-OH-DPAT (inhibiting 5-HT neurons via 5-HT1A autoreceptors). Neither of these drugs substantially altered baseline activity, however, both abolished hypercapnic responses of the respiratory network. These data illustrate that 5-HT neurons and 5-HT receptor activation are not required for respiratory rhythm generation per se, but are critical for CO2 responses in situ, supporting the hypothesis that 5-HT neurons play an important role in central ventilatory chemosensitivity in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.