Evidence map›Paper›PMID 23454060›Full record

ArticleHeart rhythm2013

A clinical feasibility study of atrial and ventricular electromechanical wave imaging.

Jean Provost, Alok Gambhir, John Vest, Hasan Garan, Elisa E Konofagou

Open access · greenAbstract read
In one paragraph

Article in Heart rhythm, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
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  6. Cardiac Resynchronization Therapy Response Assessment with Electromechanical Activation Mapping within 24 Hours of Device Implantation: A Pilot Study.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021
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  8. Review
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  15. Cardiac Strain Imaging With Coherent Compounding of Diverging Waves.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  16. Article
  17. Article
  18. Apodized adaptive beamformer.Journal of medical ultrasonics (2001) · 2017
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  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jean ProvostDepartment of Biomedical Engineering, Columbia University, New York, New York 10027, USA.
Alok Gambhir
John Vest
Hasan Garan
Elisa E Konofagou
Columbia University · US

Funding

EARLY DETECTION AND MAPPING OF ISCHEMIA USING MYOCARDIAL ELASTOGRAPHYR01EB006042 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2006 to 2018
$4.3M
Noninvasive arrhythmia mapping using Electromechanical Wave ImagingR01HL114358 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2012 to 2016
$1.9M
Noninvasive conduction mapping using Electromechanical Wave ImagingR21HL096094 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI KONOFAGOU, ELISA E. · 2009 to 2010
$446k
NHLBI NIH HHS R01 HL114358NHLBI NIH HHS R01HL114358NHLBI NIH HHS R21 HL096094NHLBI NIH HHS R21HL096094NIBIB NIH HHS R01 EB006042NIBIB NIH HHS R01EB006042
6 · The paper itself

Abstract

backgroundCardiac resynchronization therapy (CRT) and atrial ablation procedures currently lack a noninvasive imaging modality for reliable treatment planning and monitoring. Electromechanical wave imaging (EWI) is an ultrasound-based method that has previously been shown to be capable of noninvasively and transmurally mapping the activation sequence of the heart in animal studies by estimating and imaging the electromechanical wave, that is, the transient strains occurring in response to the electrical activation, at both high temporal and spatial resolutions.

objectiveTo demonstrate the feasibility of transthoracic EWI for mapping the activation sequence during different cardiac rhythms in humans.

methodsEWI was perfor`med in patients undergoing CRT and a left bundle branch block (LBBB) during sinus rhythm, left ventricular pacing, and right ventricular pacing, as well as in patients with atrial flutter (AFL) before intervention, EWI findings from patients with AFL were subsequently correlated with results from invasive intracardiac electrical mapping studies during intervention. In addition, the feasibility of single-heartbeat EWI at 2000 frames/s is demonstrated in humans for the first time in a patient with both AFL and right bundle branch block (RBBB).

resultsThe electromechanical activation maps demonstrated the capability of EWI to localize the pacing sites and characterize the bundle branch block activation sequence transmurally in patients with CRT. In patients with AFL, the EWI propagation patterns obtained with EWI were in excellent agreement with those obtained from invasive intracardiac mapping studies.

conclusionsOur findings demonstrate the potential capability of EWI to aid in the assessment and follow-up of patients undergoing CRT pacing therapy and atrial ablation, with preliminary validation in vivo.

Indexed as

Cardiac Resynchronization TherapyAdultArrhythmias, CardiacBody Surface Potential MappingBundle-Branch BlockCatheter AblationElectrophysiologic Techniques, CardiacFeasibility StudiesHeart AtriaHeart Conduction SystemHeart VentriclesHumansImage Processing, Computer-AssistedUltrasonographyYoung Adult

Identifiers

PMID23454060
PMCPMC4005774
OpenAlexW2092810693

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.