ArticleCurrent biology : CB2013
Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster.
Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- microRNAs affecting development of body pigmentation in adult Drosophila melanogaster.bioRxiv : the preprint server for biology · 2026Article
- Mapping of genotype-by-environment interaction loci for Metabolic Syndrome-like traits using the multi-parentbioRxiv : the preprint server for biology · 2025Article
- Temporal miRNA Biomarkers for Pupal Age Estimation inInsects · 2025Article
- Heterochrony in orthodenticle expression is associated with ommatidial size variation between Drosophila species.BMC biology · 2025Article
- The molecular basis of phenotypic evolution: beyond the usual suspects.Trends in genetics : TIG · 2024Review
- Characterisation of the role and regulation ofFrontiers in cell and developmental biology · 2023Article
- Temperature-dependent Small RNA Expression Depends on Wild Genetic Backgrounds of Caenorhabditis briggsae.Molecular biology and evolution · 2022Article
- Trichomes on female reproductive tract: rapid diversification and underlying gene regulatory network in Drosophila suzukii and its related species.BMC ecology and evolution · 2022Article
- Micromanagement ofJournal of developmental biology · 2022Review
- Evolution after Whole-Genome Duplication: Teleost MicroRNAs.Molecular biology and evolution · 2021Article
- A comparative analysis of heart microRNAs in vertebrates brings novel insights into the evolution of genetic regulatory networks.BMC genomics · 2021Article
- Review
- Quantifying the extent of morphological homoplasy: A phylogenetic analysis of 490 characters inEvolution letters · 2019Article
- Modulation and Evolution of Animal Development through microRNA Regulation of Gene Expression.Genes · 2019Review
- MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in aDevelopment (Cambridge, England) · 2018Article
- Gene regulatory network architecture in different developmental contexts influences the genetic basis of morphological evolution.PLoS genetics · 2018Article
- Pervasive microRNA Duplication in Chelicerates: Insights from the Embryonic microRNA Repertoire of the Spider Parasteatoda tepidariorum.Genome biology and evolution · 2016Article
- Comparative genomic analysis of upstream miRNA regulatory motifs in Caenorhabditis.RNA (New York, N.Y.) · 2016Article
- The Role of microRNAs in the Repeated Parallel Diversification of Lineages of Midas Cichlid Fish from Nicaragua.Genome biology and evolution · 2016Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 5 institutions in 4 countries.
Funding
Abstract
Identifying the genetic mechanisms underlying phenotypic change is essential to understanding how gene regulatory networks and ultimately the genotype-to-phenotype map evolve. It is recognized that microRNAs (miRNAs) have the potential to facilitate evolutionary change [1-3]; however, there are no known examples of natural morphological variation caused by evolutionary changes in miRNA expression. Therefore, the contribution of miRNAs to evolutionary change remains unknown [1, 4]. Drosophila melanogaster subgroup species display a portion of trichome-free cuticle on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. simulans [5, 6]. However, naked valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 μm(2). We investigated the genetic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbaby (svb) [7, 8] contributes to this morphological difference. Instead, we show that changes in mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9]. Therefore, our results reveal a novel mechanism for morphological evolution and suggest that modulation of the expression of miRNAs potentially plays a prominent role in generating organismal diversity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.