ArticleLancet (London, England)2013
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
Article in Lancet (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 2 registered trials, which are not on this map. Cited by 1,492 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Family/Molecular Genetic Study to Validate Research Domain Criteria
Establishing the Incidence of Tako-tsubo Cardiomyopathy in Scotland - the STARR Study
Who cites it
1,492 citing papers in PubMed, 11 syntheses or guidelines pooled it, 3,085 citations in OpenAlex.
- Identification of common spontaneous brain activity alterations across psychiatric disorders.Translational psychiatry · 2026Pooled it
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Epigenetics of bipolar disorder: a bibliometric landscape and visualization analysis.Frontiers in psychiatry · 2026Pooled it
- Between Depression and Risk of Hypertension: A Systematic Review and Meta-Analysis.Brain and behavior · 2025Pooled it
- Genetics of catatonia: a systematic review of case reports and a gene pathway analysis.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.BMC gastroenterology · 2024Pooled it
- Neurophysiological profiles of patients with bipolar disorders as probed with transcranial magnetic stimulation: A systematic review.Neuropsychopharmacology reports · 2024Pooled it
- Epidemiological and Genetic Analyses of Schizophrenia and Breast Cancer.Schizophrenia bulletin · 2024Pooled it
- Meta-analysis of 46,000 germline de novo mutations linked to human inherited disease.Human genomics · 2024Pooled it
- Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration.Nature communications · 2023Pooled it
- Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.Neuroscience and biobehavioral reviews · 2023Pooled it
- A Genome-Wide Association Study of Premenstrual Symptoms in Two Nordic Populations.Biological psychiatry global open science · 2026Article
- The Omnicausal Model Reveals the Highly Polyfactorial Nature of Complex Diseases.Genetic epidemiology · 2026Article
- Identification of comprehensive genetic factors, pathways, and shared genetic architecture of putamen volume in adolescent cohort.Translational psychiatry · 2026Article
- Metabolic Gating and the Evolution of Human Cognitive Plasticity: A Comparative Genomic Analysis.bioRxiv : the preprint server for biology · 2026Article
- Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms.Schizophrenia bulletin · 2026Article
- State-Dependent Transcriptomic Collapse of the Brain's Lactate and Ketone Thermodynamic Sensors in Schizophrenia.bioRxiv : the preprint server for biology · 2026Article
- The ventral/anterior hippocampus as a central hub for stress-related dopaminergic circuit dysfunction in psychiatric disorders.Molecular psychiatry · 2026Review
- Comprehensive analysis of interactions between brain aging and late-onset psychoses using heuristic mapping models.Communications medicine · 2026Article
- Effect of ancestry and shared genetic architecture of serious mental illness on symptoms and cognition in an admixed Latin American population.Research square · 2026Article
1,432 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
- Erratum issued
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundFindings from family and twin studies suggest that genetic contributions to psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to identify specific variants underlying genetic effects shared between the five disorders in the Psychiatric Genomics Consortium: autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia.
methodsWe analysed genome-wide single-nucleotide polymorphism (SNP) data for the five disorders in 33,332 cases and 27,888 controls of European ancestory. To characterise allelic effects on each disorder, we applied a multinomial logistic regression procedure with model selection to identify the best-fitting model of relations between genotype and phenotype. We examined cross-disorder effects of genome-wide significant loci previously identified for bipolar disorder and schizophrenia, and used polygenic risk-score analysis to examine such effects from a broader set of common variants. We undertook pathway analyses to establish the biological associations underlying genetic overlap for the five disorders. We used enrichment analysis of expression quantitative trait loci (eQTL) data to assess whether SNPs with cross-disorder association were enriched for regulatory SNPs in post-mortem brain-tissue samples.
findingsSNPs at four loci surpassed the cutoff for genome-wide significance (p<5×10(-8)) in the primary analysis: regions on chromosomes 3p21 and 10q24, and SNPs within two L-type voltage-gated calcium channel subunits, CACNA1C and CACNB2. Model selection analysis supported effects of these loci for several disorders. Loci previously associated with bipolar disorder or schizophrenia had variable diagnostic specificity. Polygenic risk scores showed cross-disorder associations, notably between adult-onset disorders. Pathway analysis supported a role for calcium channel signalling genes for all five disorders. Finally, SNPs with evidence of cross-disorder association were enriched for brain eQTL markers.
interpretationOur findings show that specific SNPs are associated with a range of psychiatric disorders of childhood onset or adult onset. In particular, variation in calcium-channel activity genes seems to have pleiotropic effects on psychopathology. These results provide evidence relevant to the goal of moving beyond descriptive syndromes in psychiatry, and towards a nosology informed by disease cause.
fundingNational Institute of Mental Health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.