Evidence map›Paper›PMID 23453733›Full record

ArticleJournal of comparative pathology2013

Koch's postulates and the pathogenesis of comparative infectious disease causation associated with Bartonella species.

E B Breitschwerdt, K L Linder, M J Day, R G Maggi, B B Chomel, V A J Kempf

Open access · greenAbstract readComment
In one paragraph

Article in Journal of comparative pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cat scratch disease: What to do with the cat?American journal of ophthalmology case reports · 2022
    Article
  6. SuspectedClinical case reports · 2021
    Article
  7. Pathogens (Basel, Switzerland) · 2021
    Article
  8. Pathogens (Basel, Switzerland) · 2020
    Article
  9. Bartonella rochalimae, a newly recognized pathogen in dogs.Journal of veterinary internal medicine · 2020
    Article
  10. Article
  11. Journal of central nervous system disease · 2019
    Article
  12. Necrotizing interstitial pneumonia and suppurative myocarditis associated with Bartonella henselae infection in three Florida pumas.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2018
    Article
  13. Article
  14. Phylogeny and putative virulence gene analysis of Bartonella bovis.The Journal of veterinary medical science · 2018
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

E B BreitschwerdtIntracellular Pathogens Research Laboratory, Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. ed_breitschwerdt@ncsu.edu
K L Linder
M J Day
R G Maggi
B B Chomel
V A J Kempf
North Carolina State University · USGoethe University Frankfurt · DEThird Way · USUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In his homage to Lucretius ('Georgica'), Vergil is credited with stating: 'Felix qui potuit rerum cognoscere causas' ('Fortunate is he who knows the causes of things'). Based on numerous commentaries and publications it is obvious that clinicians, diagnosticians and biomedical research scientists continue to struggle with disease causation, particularly in the assessment of the pathogenic role of 'stealth pathogens' that produce persistent infections in the host. Bartonella species, because of their evolutionary ability to induce persistent intravascular infections, present substantial challenges for researchers attempting to clarify the ability of these stealth bacteria to cause disease. By studying the comparative biological and pathological behaviour of microbes across mammalian genera, researchers might be able more rapidly to advance medical science and, subsequently, patient care by undertaking focused research efforts involving a single mammalian species or by attempting to recapitulate a complex disease in an rodent model. Therefore, in an effort to further assist in the establishment of disease causation by stealth pathogens, we use recent research observations involving the genus Bartonella to propose an additional postulate of comparative infectious disease causation to Koch's postulates.

Indexed as

Communicable Disease ControlCommunicable DiseasesHumansTuberculosis

Identifiers

PMID23453733
PMCPMC7094375
OpenAlexW1995967999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.