ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2013
Key considerations and current perspectives of epidemiological studies on human papillomavirus persistence, the intermediate phenotype to cervical cancer.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Cervical HPV natural history among young Western Cape, South African women: The randomized control EVRI Trial.The Journal of infection · 2016Trial
- Fecal sample biobanking for breast cancer research focused on the gut microbiome.medRxiv : the preprint server for health sciences · 2025Article
- The role of HR-HPV integration in the progression of premalignant lesions into different cancer types.Heliyon · 2024Review
- PAX1 methylation as a robust predictor: developing and validating a nomogram for assessing endocervical curettage (ECC) necessity in human papillomavirus16/18-positive women undergoing colposcopy.Clinical epigenetics · 2024Article
- Human papillomavirus and cervical cancer in the microbial world: exploring the vaginal microecology.Frontiers in cellular and infection microbiology · 2024Review
- Effect of Human Immunodeficiency Virus Infection on Human Papillomavirus Clearance Among Women in Senegal, West Africa.The Journal of infectious diseases · 2023Article
- The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS.Annals of medicine · 2022Review
- Triage by PAX1 and ZNF582 Methylation in Women With Cervical Intraepithelial Neoplasia Grade 3: A Multicenter Case-Control Study.Open forum infectious diseases · 2022Article
- The application of CRISPR/Cas9 system in cervical carcinogenesis.Cancer gene therapy · 2022Article
- E7-Targeted Nanotherapeutics for Key HPV Afflicted Cervical Lesions by Employing CRISPR/Cas9 and Poly (Beta-Amino Ester).International journal of nanomedicine · 2021Article
- A Review on Inosine Pranobex Immunotherapy for Cervical HPV-Positive Patients.Infection and drug resistance · 2021Review
- Vaginal microbiomes and ovarian cancer: a review.American journal of cancer research · 2020Review
- Variants in immune-related genes and genital HPV 16 persistence in men.Papillomavirus research (Amsterdam, Netherlands) · 2019Article
- Association of HLA-DRB1/DQB1 polymorphism with high-risk HPV infection and cervical intraepithelial neoplasia women from Shanghai.International journal of clinical and experimental pathology · 2018Article
- Cutaneous Papillomaviruses and Non-melanoma Skin Cancer: Causal Agents or Innocent Bystanders?Frontiers in microbiology · 2018Review
- Predictors of HPV incidence and clearance in a cohort of Brazilian HIV-infected women.PloS one · 2017Article
- Prevalence, Genotype Distribution and Risk Factors for Cervical Human Papillomavirus Infection in the Grand Tunis Region, Tunisia.PloS one · 2016Article
- TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy.The Journal of clinical investigation · 2015Article
- Functional variants in CYP1A1 and GSTM1 are associated with clearance of cervical HPV infection.Gynecologic oncology · 2014Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Persistent infection with human papillomavirus (HPV) causes essentially all precancerous cervical lesions and cervical cancer in females and thus is an important intermediate phenotype to cervical cancer. A majority of infected individuals naturally clear HPV viral infection, but the virus persists in a subset of infected hosts and the mechanism for this differential outcome is not well described. Most of the epidemiological studies have been cross-sectional in nature, and even with longitudinal studies, the definition of HPV persistence or clearance has not been well defined. There is no consensus on the correct time interval between HPV DNA tests, or how to utilize HPV persistence information in clinical management because there is no treatment for HPV. While most studies are performed with the endpoint of cancer, the intermediate phenotype has been overlooked. Epidemiological studies of HPV persistence suffer with several challenges in definitions, study designs, and analyses that undermine its importance in identifying and understanding the interactions between the viral and host genomes in the process of HPV infection pathogenesis. We have evaluated the current status of HPV persistence and provide perspectives on how the field would benefit from a research focus on intermediate phenotype in epidemiological studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.