ReviewCurrent opinion in neurobiology2013
The multiple facets of opioid receptor function: implications for addiction.
Review in Current opinion in neurobiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.
- Functional genomic mechanisms of opioid action and opioid use disorder: a systematic review of animal models and human studies.Molecular psychiatry · 2023Pooled it
- Low-Dose Naltrexone for Chronic Pain: Update and Systemic Review.Current pain and headache reports · 2020Pooled it
- Effects of Buprenorphine on Responses to Emotional Stimuli in Individuals with a Range of Mood Symptomatology.The international journal of neuropsychopharmacology · 2018Trial
- Sustained Benefits of Exercise-based Motivational Interviewing, but Only among Nonusers of Opioids in Patients with Fibromyalgia.The Journal of rheumatology · 2017Trial
- Exploring the addictive potential of α-methylfentanyl and acetyl-α-methylfentanyl in animal models.Psychopharmacology · 2026Article
- Two pore domain THIK2 potassium channels regulate acute and chronic pain signaling.Pain reports · 2026Article
- Chronic morphine differentially impacts glutamatergic synaptic plasticity in the ventral tegmental area of adult versus adolescent mice.Neuropharmacology · 2026Article
- Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.Addiction biology · 2026Article
- Structure-Guided Repurposing of Approved Drugs Identifies Aprepitant and Mavorixafor as Putative δ-Opioid Receptor Agonist Candidates.International journal of molecular sciences · 2026Article
- Association Between Heroin Use and Depression: NHANES 2005-2018.Addiction biology · 2026Article
- Transcriptional response to chronic long-access fentanyl self-administration in rat habenula and amygdala.bioRxiv : the preprint server for biology · 2025Article
- Disrupted maternal behavior in morphine-dependent pregnant rats and anhedonia in their offspring.Neuropharmacology · 2025Article
- Similarities and Differences in Neurobiology.Advances in experimental medicine and biology · 2025Review
- Disrupted Maternal Behavior in Morphine-Dependent Pregnant Rats and Anhedonia in their Offspring.bioRxiv : the preprint server for biology · 2024Article
- Opioid drug seeking after early-life adversity: a role for delta opioid receptors.Addiction neuroscience · 2024Article
- Genetic Variants Linked to Opioid Addiction: A Genome-Wide Association Study.International journal of molecular sciences · 2024Article
- Novel medications for problematic alcohol use.The Journal of clinical investigation · 2024Review
- TheFrontiers in psychology · 2024Article
- Endogenous and Exogenous Opioids: Role in Substance Use Disorders.Advances in neurobiology · 2024Review
- Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice.The Journal of clinical investigation · 2023Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Addiction is characterized by altered reward processing, disrupted emotional responses and poor decision-making. Beyond a central role in drug reward, increasing evidence indicate that opioid receptors are broadly involved in all these processes. Recent studies establish the mu opioid receptor as a main player in social reward, which attracts increasing attention in psychiatric research. There is growing interest in blocking the kappa opioid receptor to prevent relapse, and alleviate the negative affect of withdrawal. The delta opioid receptor emerges as a potent mood enhancer, whose involvement in addiction is less clear. All three opioid receptors are likely implicated in addiction-depression comorbidity, and understanding of their roles in cognitive deficits associated to drug abuse is only beginning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.