Evidence map›Paper›PMID 23453689›Full record

ReviewCurrent opinion in genetics & development2013

Multi-disciplinary methods to define RNA-protein interactions and regulatory networks.

Manuel Ascano, Stefanie Gerstberger, Thomas Tuschl

Abstract readReview
In one paragraph

Review in Current opinion in genetics & development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members.International journal of molecular sciences · 2018
    Review
  14. Article
  15. Review
  16. Article
  17. Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  18. Article
  19. Article
  20. Novel RNA-Binding Proteins Isolation by the RaPID Methodology.Journal of visualized experiments : JoVE · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Manuel AscanoHoward Hughes Medical Institute and Laboratory for RNA Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, United States.
Stefanie Gerstberger
Thomas Tuschl

Funding

Posttranscriptional regulation by mRNA-binding shuttling and transport proteinsR01GM104962 · NIGMS · ROCKEFELLER UNIVERSITY · PI OHLER, UWE, PATEL, DINSHAW J · 2012 to 2016
$4.4M
miRNA Gene Regulatory Networks and their Role in Diseases of the Nervous SystemR01MH080442 · NIMH · ROCKEFELLER UNIVERSITY · PI TUSCHL, THOMAS · 2007 to 2011
$2.8M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM104962NIMH NIH HHS R01 MH080442
6 · The paper itself

Abstract

The advent of high-throughput technologies including deep-sequencing and protein mass spectrometry is facilitating the acquisition of large and precise data sets toward the definition of post-transcriptional regulatory networks. While early studies that investigated specific RNA-protein interactions in isolation laid the foundation for our understanding of the existence of molecular machines to assemble and process RNAs, there is a more recent appreciation of the importance of individual RNA-protein interactions that contribute to post-transcriptional gene regulation. The multitude of RNA-binding proteins (RBPs) and their many RNA targets has only been captured experimentally in recent times. In this review, we will examine current multidisciplinary approaches toward elucidating RNA-protein networks and their regulation.

Indexed as

Gene Regulatory NetworksRNA Processing, Post-TranscriptionalGene Expression ProfilingGene LibraryHigh-Throughput Nucleotide SequencingHumansRNA-Binding ProteinsRNA, MessengerRNA-Binding ProteinsRNA, Messenger

Identifiers

PMID23453689
PMCPMC3624891

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.