ArticleAmerican journal of human genetics2013
An African American paternal lineage adds an extremely ancient root to the human Y chromosome phylogenetic tree.
Article in American journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers.
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53 citing papers in PubMed, 143 citations in OpenAlex.
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- Y-mer: a k-mer based method for determining human Y chromosome haplogroups from ultra-low sequencing depth data.Genome biology · 2025Article
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- Genome-wide association study identifies novel candidate malaria resistance genes in Cameroon.Human molecular genetics · 2023Article
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- Paleogenomes Reveal a Complex Evolutionary History of Late Pleistocene Bison in Northeastern China.Genes · 2022Article
- Placing Ancient DNA Sequences into Reference Phylogenies.Molecular biology and evolution · 2022Article
- New insights into the evolution of human Y chromosome palindromes through mutation and gene conversion.Human molecular genetics · 2021Article
- Article
- Origins of modern human ancestry.Nature · 2021Review
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- Y-Chromosome Variation in Southern African Khoe-San Populations Based on Whole-Genome Sequences.Genome biology and evolution · 2020Article
- Article
- A Rare Deep-Rooting D0 African Y-Chromosomal Haplogroup and Its Implications for the Expansion of Modern Humans Out of Africa.Genetics · 2019Article
- Selection Has Countered High Mutability to Preserve the Ancestral Copy Number of Y Chromosome Amplicons in Diverse Human Lineages.American journal of human genetics · 2018Article
- Did Our Species Evolve in Subdivided Populations across Africa, and Why Does It Matter?Trends in ecology & evolution · 2018Article
- On the joint distribution of tree height and tree length under the coalescent.Theoretical population biology · 2018Article
- Carriers of mitochondrial DNA macrohaplogroup L3 basal lineages migrated back to Africa from Asia around 70,000 years ago.BMC evolutionary biology · 2018Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report the discovery of an African American Y chromosome that carries the ancestral state of all SNPs that defined the basal portion of the Y chromosome phylogenetic tree. We sequenced ∼240 kb of this chromosome to identify private, derived mutations on this lineage, which we named A00. We then estimated the time to the most recent common ancestor (TMRCA) for the Y tree as 338 thousand years ago (kya) (95% confidence interval = 237-581 kya). Remarkably, this exceeds current estimates of the mtDNA TMRCA, as well as those of the age of the oldest anatomically modern human fossils. The extremely ancient age combined with the rarity of the A00 lineage, which we also find at very low frequency in central Africa, point to the importance of considering more complex models for the origin of Y chromosome diversity. These models include ancient population structure and the possibility of archaic introgression of Y chromosomes into anatomically modern humans. The A00 lineage was discovered in a large database of consumer samples of African Americans and has not been identified in traditional hunter-gatherer populations from sub-Saharan Africa. This underscores how the stochastic nature of the genealogical process can affect inference from a single locus and warrants caution during the interpretation of the geographic location of divergent branches of the Y chromosome phylogenetic tree for the elucidation of human origins.
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