ArticleUltrasound in medicine & biology2013
Clot retraction affects the extent of ultrasound-enhanced thrombolysis in an ex vivo porcine thrombosis model.
Article in Ultrasound in medicine & biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 91 citations in OpenAlex.
- Cavitation-vibration coupling mechanism in ultrasonic guidewire vascular ablation.Ultrasonics sonochemistry · 2025Article
- Self-Sensing with Hollow Cylindrical Transducers for Histotripsy-Enhanced Aspiration Mechanical Thrombectomy Applications.Sensors (Basel, Switzerland) · 2025Article
- Dissolving porcine and human microthrombi by short exposure to microdoses of alteplase in an in vitro model of microvascular obstruction.Scientific reports · 2025Article
- Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Review
- Histotripsy and Catheter-Directed Lytic: Efficacy in Highly Retracted Porcine Clots In Vitro.Ultrasound in medicine & biology · 2024Article
- A Quantitative Method for the Evaluation of Deep Vein Thrombosis in a Murine Model Using Three-Dimensional Ultrasound Imaging.Biomedicines · 2024Article
- Factors influencing the efficacy of recombinant tissue plasminogen activator: Implications for ischemic stroke treatment.PloS one · 2024Article
- Effect of Recombinant Tissue Plasminogen Activator and 120-kHz Ultrasound on Porcine Intracranial Thrombus Density.Ultrasound in medicine & biology · 2023Article
- Blood clot contraction: Mechanisms, pathophysiology, and disease.Research and practice in thrombosis and haemostasis · 2023Article
- Estimating Thrombus Elasticity by Shear Wave Elastography to Evaluate Ultrasound Thrombolysis for Thrombus With Different Stiffness.IEEE transactions on bio-medical engineering · 2023Article
- Augmentation of Pulmonary Perfusion by Conducted Effects of a Pulmonary Artery Ultrasound Catheter.Ultrasound in medicine & biology · 2022Article
- Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility.Ultrasound in medicine & biology · 2022Article
- Ultrasound-Guided Intravascular Sonothrombolysis With a Dual Mode Ultrasound Catheter: In Vitro Study.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery.Biomedical engineering letters · 2022Article
- An Analysis of Sonothrombolysis and Cavitation for Retracted and Unretracted Clots Using Microbubbles Versus Low-Boiling-Point Nanodroplets.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Contrast Ultrasound, Sonothrombolysis and Sonoperfusion in Cardiovascular Disease: Shifting to Theragnostic Clinical Trials.JACC. Cardiovascular imaging · 2022Review
- Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery.Ultrasonics sonochemistry · 2021Review
- In Vivo Porcine Aged Deep Vein Thrombosis Model for Testing Ultrasound-based Thrombolysis Techniques.Ultrasound in medicine & biology · 2021Article
- Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study.Ultrasound in medicine & biology · 2021Article
- Magneto-sonothrombolysis with combination of magnetic microbubbles and nanodroplets.Ultrasonics · 2021Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We investigated ultrasound-enhanced thrombolysis in two whole-blood clot models using a Food and Drug Administration-approved contrast agent (Definity, Lantheus Medical Imaging; Billerica, MA USA) and thrombolytic drug (recombinant tissue-type plasminogen activator [rt-PA]) (Genentech; South San Francisco, CA USA). Porcine venous blood was collected from donor hogs and coagulated in vials made of two different materials. This method produced clots with differing compositional properties, as determined by routine scanning electron microscopy and histology. Clots were deployed in an ex vivo porcine thrombosis model, and exposed to an intermittent ultrasound scheme previously developed to maximize stable cavitation while acoustic emissions were detected. Exposure to 3.15 μg/mL rt-PA promoted lysis in both clot models, compared with exposure to plasma alone. However, only unretracted clots experienced significant enhancement of thrombolysis in the presence of rt-PA, Definity, and ultrasound, compared with treatment with rt-PA. In these clots, microscopy revealed loose erythrocyte aggregates, a significantly less extensive fibrin network and a higher porosity, which may facilitate increased penetration of thrombolytics by cavitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.