Evidence map›Paper›PMID 23453528›Full record

ReviewBlood cells, molecules & diseases2013

Hematopoietic stem cells are pluripotent and not just "hematopoietic".

Makio Ogawa, Amanda C LaRue, Meenal Mehrotra

Abstract readReview
In one paragraph

Review in Blood cells, molecules & diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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  13. Is genetic rescue of cystinosis an achievable treatment goal?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Makio OgawaDepartment of Pathology and Laboratory Medicine, Ralph H. Johnson VAMC, USA. ogawam@musc.edu
Amanda C LaRue
Meenal Mehrotra

Funding

Hematopoietic Stem Cell-Derived Carcinoma Associated Fibroblasts in TumorR01CA148772 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LARUE, AMANDA C. · 2011 to 2015
$1.3M
Hematopoietic Stem Cell Transplantation in Osteogenesis ImperfectaK01AR059097 · NIAMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEHROTRA, MEENAL · 2010 to 2012
$207k
Potential of Hematopoietic Stem Cell-Based Therapies for Complicated FracturesI01BX000333 · VA · RALPH H JOHNSON VA MEDICAL CENTER · PI LARUE, AMANDA C. · 2009 to 2022
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BLRD VA I01 BX000333NCI NIH HHS R01 CA148772NIAMS NIH HHS K01 AR059097
6 · The paper itself

Abstract

Over a decade ago, several preclinical transplantation studies suggested the striking concept of the tissue-reconstituting ability (often referred to as HSC plasticity) of hematopoietic stem cells (HSCs). While this heralded an exciting time of radically new therapies for disorders of many organs and tissues, the concept was soon mired in controversy and remained dormant for almost a decade. This commentary provides a concise review of evidence for HSC plasticity, including more recent findings based on single HSC transplantation in mouse and clinical transplantation studies. There is strong evidence for the concept that HSCs are pluripotent and are the source for the majority, if not all, of the cell types in our body. Also discussed are some biological and experimental issues that need to be considered in the future investigation of HSC plasticity.

Indexed as

AnimalsCell DifferentiationCell LineageGenetic Diseases, InbornHematopoietic Stem CellsHematopoietic Stem Cell TransplantationHumansPluripotent Stem Cells

Identifiers

PMID23453528
PMCPMC3646972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.