Trial reportActa veterinaria Scandinavica2013
Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-κB and Nrf2 in the duodenal mucosa of pigs.
Trial report in Acta veterinaria Scandinavica, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it, 130 citations in OpenAlex.
- Pooled it
- Oxidative stress and food supplementation with antioxidants in therapy dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2017Trial
- Effects of dietary polyphenol-rich plant products from grape or hop on pro-inflammatory gene expression in the intestine, nutrient digestibility and faecal microbiota of weaned pigs.BMC veterinary research · 2014Trial
- Plant bioactive compounds as functional feed additives for improving livestock and poultry production: review.Animal bioscience · 2026Article
- Inclusion of unqualified cacao pod in mineral feed block: a novel strategy to improve rumen fermentation and mitigate methane emissions in beef cattle.Animal bioscience · 2026Article
- Sustainable Use of Agro-Industrial By-Products as Feed in Finishing Pigs.Veterinary sciences · 2026Article
- Effects of Grape By-Products on Oxidative Stress and Inflammation in Farm Animals: An Overview of Studies Performed in Pigs, Chickens, and Cattle.Animals : an open access journal from MDPI · 2025Review
- Antibiotics and Opportunities of Their Alternatives in Pig Production: Mechanisms Through Modulating Intestinal Microbiota on Intestinal Health and Growth.Antibiotics (Basel, Switzerland) · 2025Review
- Effect of Coffee Silverskin on Meat Quality of Growing Rabbits.Foods (Basel, Switzerland) · 2025Article
- Natural plant polyphenols contribute to the ecological and healthy swine production.Journal of animal science and biotechnology · 2024Review
- Supplementation of vitamin E or a botanical extract as antioxidants to improve growth performance and health of growing pigs housed under thermoneutral or heat-stressed conditions.Journal of animal science and biotechnology · 2024Article
- Dietary Supplementation of Tannins: Effect on Growth Performance, Serum Antioxidant Capacity, and Immunoglobins of Weaned Piglets-A Systematic Review with Meta-Analysis.Antioxidants (Basel, Switzerland) · 2024Review
- Partial Replacement of Synthetic Vitamin E by Polyphenols in Post-Weaning Piglets.Antioxidants (Basel, Switzerland) · 2023Article
- Antioxidant Activity, Metabolism, and Bioavailability of Polyphenols in the Diet of Animals.Antioxidants (Basel, Switzerland) · 2023Review
- Grape Pomace as a Cardiometabolic Health-Promoting Ingredient: Activity in the Intestinal Environment.Antioxidants (Basel, Switzerland) · 2023Review
- Flavonoids inInternational journal of molecular sciences · 2023Article
- Nutraceutical Effect of Resveratrol on the Mammary Gland: Focusing on the NF-κb /Nrf2 Signaling Pathways.Animals : an open access journal from MDPI · 2023Article
- A blend of selected botanicals maintains intestinal epithelial integrity and reduces susceptibility toFrontiers in veterinary science · 2023Article
- Article
- Botanicals as a zinc oxide alternative to protect intestinal cells from anFrontiers in veterinary science · 2023Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn pigs, enteric infections and the development of gut disorders such as diarrhoea are commonly observed, particularly after weaning. The present study investigated the hypothesis that feeding a grape seed and grape marc extract (GSGME) as a dietary supplement has the potential to suppress the inflammatory process in the small intestine of pigs by modulating the activities of NF-κB and Nrf2 due to its high content of flavonoids.
methodsTwenty-four crossbred, 6 weeks old pigs were randomly assigned to 2 groups of 12 animals each and fed nutritionally adequate diets without or with 1% GSGME for 4 weeks.
resultsPigs administered GSGME had a lower transactivation of NF-κB and Nrf2 and a lower expression of various target genes of these transcription factors in the duodenal mucosa than control pigs (P < 0.05). Concentrations of α-tocopherol and thiobarbituric acid reactive substances (TBARS) in liver and plasma and total antioxidant capacity of plasma and relative mRNA abundances of NF-κB and Nrf2 target genes in the liver did not differ between the two groups. However, the ratio of villus height:crypt depth and the gain:feed ratio was higher in the pigs fed GSGME than in control pigs (P < 0.05).
conclusionsThis study shows that dietary supplementation of a polyphenol rich GSGME suppresses the activity of NF-κB in the duodenal mucosa of pigs and thus might provide a useful dietary strategy to inhibit inflammation in the gut frequently occurring in pigs. Feeding GSGME did not influence vitamin E status and the antioxidant system of the pigs but improved the gain:feed ratio. In overall, the study suggests that polyphenol-rich plant extracts such GSGME could be useful feed supplements in pig nutrition, in order to maintain animal health and improve performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.