ArticleThe Journal of allergy and clinical immunology2013
Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children.
Article in The Journal of allergy and clinical immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of associations between environmental exposures and development of asthma in children aged up to 9 years.BMJ open · 2014Pooled it
- Dental sealants and flowable composite restorations and psychosocial, neuropsychological, and physical development in children.Pediatric dentistryTrial
- BPM Exposure Induces Pulmonary Dysfunction in Adult Mice and Adverse Intergenerational Pulmonary Effects in Offspring.Environment & health (Washington, D.C.) · 2026Article
- Prenatal exposure to environmental phenolic compounds and their association with childhood atopic dermatitis, asthma, and allergic rhinitis in the ECHO cohort.Environment international · 2025Article
- Prenatal exposure to environmental bisphenols over time and their association with childhood asthma, allergic rhinitis and atopic dermatitis in the ECHO consortium.Environmental pollution (Barking, Essex : 1987) · 2025Article
- Guardians under Siege: Exploring Pollution's Effects on Human Immunity.International journal of molecular sciences · 2024Review
- Trajectory analysis of rhinitis in a birth cohort from lower-income New York City neighborhoods.The Journal of allergy and clinical immunology · 2024Article
- Implications of Prenatal Exposure to Endocrine-Disrupting Chemicals in Offspring Development: A Narrative Review.Nutrients · 2024Review
- Cohort Profile: The Mothers and Newborns (MN) Cohort of the Columbia Center for Children's Environmental Health.International journal of epidemiology · 2024Article
- Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort.Environmental health : a global access science source · 2024Article
- Prenatal exposure to replacement flame retardants and organophosphate esters and childhood adverse respiratory outcomes.Environmental research · 2024Article
- Associations between mitochondrial biomarkers, urban residential exposures and childhood asthma outcomes over 6 months.Environmental research · 2023Article
- Synthetic Chemicals: What We Have Learned and Still Need to Learn About Their Associations with Childhood Allergy and Asthma.Current environmental health reports · 2023Review
- Review
- A review on immunomodulatory effects of BPA analogues.Archives of toxicology · 2023Review
- Prenatal bisphenol A and S exposure and atopic disease phenotypes at age 6.Environmental research · 2023Article
- Potential effects of bisphenol A on diabetes mellitus and its chronic complications: A narrative review.Heliyon · 2023Review
- Environmental estrogen exposures alter molecular signaling in immune cells that promote the development of childhood asthma.Molecular immunology · 2023Article
- Re-evaluation of the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs.EFSA journal. European Food Safety Authority · 2023Article
- Anti-inflammatory effects ofToxicological research · 2023Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundBisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation.
objectivesWe hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (Feno) values in children.
methodsThe Columbia Center for Children's Environmental Health recruited pregnant women for a prospective birth cohort study (n = 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. Feno values were measured at ages 7 to 11 years.
resultsPrenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P = .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P = .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P = .03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P = .04) and Feno values (β = 0.1; 95% CI, 0.02-0.2; P = .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively).
conclusionsThis is the first report of an association between postnatal urinary BPA concentrations and asthma in children.
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