Evidence map›Paper›PMID 23452682›Full record

Trial reportJournal of the American Academy of Child and Adolescent Psychiatry2013

Adolescent substance use in the multimodal treatment study of attention-deficit/hyperactivity disorder (ADHD) (MTA) as a function of childhood ADHD, random assignment to childhood treatments, and subsequent medication.

Brooke S G Molina, Stephen P Hinshaw, L Eugene Arnold, James M Swanson, William E Pelham, Lily Hechtman, Betsy Hoza, Jeffery N Epstein, Timothy Wigal, Howard B Abikoff and 11 more

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Academy of Child and Adolescent Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000388 (Multimodal Treatment Study of Children With ADHD), which is not on this map. Cited by 131 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 7 pooled it
18.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000388 phase4completednot on this map

Multimodal Treatment Study of Children With ADHD

TypeinterventionalSponsorNYU Langone HealthRan1998 to 1999ConditionsAttention Deficit Disorder With Hyperactivity, Substance-related Disorders, Dyssocial BehaviorArmsPsychosocial treatment, Anti-ADHD medication, Assessment-and-Referral
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 7 syntheses or guidelines pooled it, 246 citations in OpenAlex.

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  14. Randomized Trial of Academic Training and Medication Decision-Making for Adolescents with ADHD in Usual Care.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
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71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 15 institutions in 3 countries.

Brooke S G MolinaDepartment of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA. molinab@upmc.edu
Stephen P Hinshaw
L Eugene Arnold
James M Swanson
William E Pelham
Lily Hechtman
Betsy Hoza
Jeffery N Epstein
Timothy Wigal
Howard B Abikoff
Laurence L Greenhill
Peter S Jensen
Karen C Wells
Benedetto Vitiello
Robert D Gibbons
Andrea Howard
Patricia R Houck
Kwan Hur
Bo Lu
Sue Marcus
MTA Cooperative Group
Columbia University · USThe Ohio State University · USUniversity of California, Irvine · USDuke University · USFlorida International University · USMcGill University · CANew York University · USRealistic Education in Action Coalition to Foster Health · USUniversity of California, Berkeley · USUniversity of Chicago · USUniversity of Cincinnati · USUniversity of Illinois Chicago · USUniversity of Pittsburgh · USUniversity of Pittsburgh Medical Center · USUniversity of Vermont · US

Funding

MULTISITE MULTIMODALITY TREATMENT STUDY OF ADHD/ADDU01MH050440 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI SWANSON, JAMES M · 1992 to 2000
$17k
MULTISITE MULTIMODAL TREATMENT STUDY OF ADHD/ADDU01MH050453 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABIKOFF, HOWARD B · 1992 to 2000
$17k
PHARMACOLOGIC AND PSYCHOSOCIAL INTERVENTIONS FOR ADHDU01MH050461 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HINSHAW, STEPHEN P · 1992 to 2000
$17k
PHARMACOLOGICAL AND PSYCHOSOCIAL TREATMENT FOR ADHDU01MH050467 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PELHAM, WILLIAM E · 1992 to 2000
$17k
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012009N01MH012009 · NIMH · UNIVERSITY OF CALIFORNIA, BERK · PI HINSHAW, STEPHEN · 2002 to 2006
–
FOLLOW UP OF THE MULTIMODAL TREATMETN STUDY OF CHILDREN WITH ATTENTION-278012010N01MH012010 · NIMH · UNIVERSITY OF PITTSBURGH · PI SG MOLINA, BROOKE · 2002 to 2006
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CELLULAR ANALYSIS OF MEMORY STAGES IN APLYSIAF32MH012004 · NIMH · YALE UNIVERSITY · PI SHERFF, CAROLYN M · 1997 to 1998
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012012N01MH012012 · NIMH · DUKE UNIVERSITY MEDICAL CENTER · 2002 to 2004
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012011N01MH012011 · NIMH · UNIVERSITY OF CALIFORNIA, IRVI · PI SWANSON, JAMES · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012004N01MH012004 · NIMH · NEW YORK UNIVERSITY SCHOOL OF · PI ABIKOFF, HOWARD BARRY · 2002 to 2006
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FOLLOW UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012007N01MH012007 · NIMH · RES. FOUND. FOR MENTAL HEALTH, · PI GREENHILL, LARRY LEE · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012008N01MH012008 · NIMH · MCGILL UNIVERSITY · PI HECHTMAN, LILY T. · 2002 to 2006
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6 · The paper itself

Abstract

objectiveTo determine long-term effects on substance use and substance use disorder (SUD), up to 8 years after childhood enrollment, of the randomly assigned 14-month treatments in the multisite Multimodal Treatment Study of Children with Attention-Deficit/Hyperactivity Disorder (MTA; n = 436); to test whether medication at follow-up, cumulative psychostimulant treatment over time, or both relate to substance use/SUD; and to compare substance use/SUD in the ADHD sample to the non-ADHD childhood classmate comparison group (n = 261).

methodMixed-effects regression models with planned contrasts were used for all tests except the important cumulative stimulant treatment question, for which propensity score matching analysis was used.

resultsThe originally randomized treatment groups did not differ significantly on substance use/SUD by the 8-year follow-up or earlier (mean age = 17 years). Neither medication at follow-up (mostly stimulants) nor cumulative stimulant treatment was associated with adolescent substance use/SUD. Substance use at all time points, including use of two or more substances and SUD, were each greater in the ADHD than in the non-ADHD samples, regardless of sex.

conclusionsMedication for ADHD did not protect from, or contribute to, visible risk of substance use or SUD by adolescence, whether analyzed as randomized treatment assignment in childhood, as medication at follow-up, or as cumulative stimulant treatment over an 8-year follow-up from childhood. These results suggest the need to identify alternative or adjunctive adolescent-focused approaches to substance abuse prevention and treatment for boys and girls with ADHD, especially given their increased risk for use and abuse of multiple substances that is not improved with stimulant medication. Clinical trial registration information-Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA); http://clinical trials.gov/; NCT00000388.

Indexed as

AdolescentAttention Deficit Disorder with HyperactivityBehavior TherapyCentral Nervous System StimulantsChildCombined Modality TherapyComorbidityFemaleFollow-Up StudiesHumansMalePsychiatric Status Rating ScalesRegression AnalysisSubstance-Related DisordersTime FactorsTreatment OutcomeCentral Nervous System Stimulants

Identifiers

PMID23452682
PMCPMC3589108
OpenAlexW2096729555

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.