ArticleBiological psychiatry2013
Cellular adaptations of dorsal raphe serotonin neurons associated with the development of active coping in response to social stress.
Article in Biological psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 73 citations in OpenAlex.
- Hypothesis on PTSD Pathophysiology: Role of CRH, Noradrenaline, and Glucocorticoid Receptors in an Amygdala-Centered Closed-Loop System.International journal of molecular sciences · 2026Article
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- A unifying theory of brain signaling and its possible role in acquired chronic disease.Frontiers in neuroscience · 2026Article
- Central amygdalaNeurobiology of stress · 2026Article
- Enduring modulation of dorsal raphe nuclei regulates (R,S)-ketamine-mediated resilient stress-coping behavior.Molecular psychiatry · 2025Article
- The role of dorsal raphe nucleus neuropeptides in reward and aversion.Frontiers in behavioral neuroscience · 2025Review
- Activation of NOP receptor increases vulnerability to stress: role of glucocorticoids and CRF signaling.Psychopharmacology · 2024Article
- Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety.Molecular psychiatry · 2023Article
- Serotonin modulates social responses to stressed conspecifics via insular 5-HTNeuropharmacology · 2023Article
- Serotonin and Dopamine Show Different Response Profiles to Acute Stress in the Nucleus Accumbens and Medial Prefrontal Cortex of Rats with Neuropathic Pain.Neurochemical research · 2023Article
- Social stress-induced serotonin dysfunction activates spexin in male Nile tilapia (Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Stress- and drug-induced neuroimmune signaling as a therapeutic target for comorbid anxiety and substance use disorders.Pharmacology & therapeutics · 2022Review
- Evolution of stress responses refine mechanisms of social rank.Neurobiology of stress · 2021Review
- Stress Alters the Effect of Alcohol on Catecholamine Dynamics in the Basolateral Amygdala.Frontiers in behavioral neuroscience · 2021Article
- CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement.Psychopharmacology · 2021Article
- Acute Corticotropin-Releasing Factor Receptor Type 2 Agonism Results in Sustained Symptom Improvement in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Frontiers in systems neuroscience · 2021Article
- Serotonergic Plasticity in the Dorsal Raphe Nucleus Characterizes Susceptibility and Resilience to Anhedonia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Corticotropin-Releasing Factor (CRF) circuit modulation of cognition and motivation.Neuroscience and biobehavioral reviews · 2019Review
- The contribution of the locus coeruleus-norepinephrine system in the emergence of defeat-induced inflammatory priming.Brain, behavior, and immunity · 2019Article
- Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundSocial stress is a risk factor for affective disorders for certain vulnerable individuals. Stress and depression are linked in part through regulation of the dorsal raphe (DR)-serotonin (5-HT) system by the stress-related neuropeptide, corticotropin-releasing factor (CRF). We used a rat social stress model that shows individual differences in coping strategies to determine whether differences in CRF-5-HT interactions underlie individual differences in the vulnerability to social stress.
methodsRats were exposed to the resident-intruder model of social stress for 5 days. In vivo single-unit recordings assessed DR-5-HT neuronal responses to CRF and immunoelectron microscopy assessed CRF1 and CRF2 cellular localization 24 hours after the last stress.
resultsRats responded to social stress passively, assuming defeat with short latencies (48%), or actively, with proactive behaviors and longer defeat latencies (LL, 52%). Whereas CRF (30 ng, intra-DR) inhibited 5-HT neuronal activity of control and SL rats, it activated 5-HT neurons of LL rats, an effect that was CRF2-mediated. Consistent with this, social stress promoted CRF1 internalization together with CRF2 recruitment to the plasma membrane of DR neurons selectively in LL rats.
conclusionsThese data suggest that a proactive coping strategy toward social stress is associated with a redistribution of CRF1 and CRF2 in DR-5-HT neurons that primes the system to be activated by subsequent stress. The lack of this adaptation in passive coping rats may contribute to their depressive-like phenotype. These studies provide a cellular mechanism for individual differences in stress responses and consequences.
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