ArticlePloS one2013
Aberrant gene expression in dogs with portosystemic shunts.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Congenital Portosystemic Shunts: A Review.Journal of clinical and translational hepatology · 2026Review
- Prediction of outcome after ligation or thin film banding of extrahepatic shunts, based on plasma albumin concentration and hematologic expression of 8 target genes in 85 dogs.Journal of veterinary internal medicine · 2023Article
- Clinical Characteristics, Serum Biochemical Changes, and Expression Profile of Serum Cfa-miRNAs in Dogs Confirmed to Have Congenital Portosystemic Shunts Accompanied by Liver Pathologies.Veterinary sciences · 2020Article
- Expression of blood hepatocyte-derived microRNA-122 in canine multicentric lymphoma with hepatic involvement.Veterinary research communications · 2019Article
- Genome-wide based model predicting recovery from portosystemic shunting after liver shunt attenuation in dogs.Journal of veterinary internal medicine · 2018Article
- Evaluation of hepatocyte-derived microRNA-122 for diagnosis of acute and chronic hepatitis of dogs.Veterinary world · 2018Article
- Lysosome-mediated degradation of a distinct pool of lipid droplets during hepatic stellate cell activation.The Journal of biological chemistry · 2017Article
- Gene expression patterns in the progression of canine copper-associated chronic hepatitis.PloS one · 2017Article
- Article
- Gene expression profiling of brain cortex microvessels may support brain vasodilation in acute liver failure rat models.Metabolic brain disease · 2016Article
- ATGL and DGAT1 are involved in the turnover of newly synthesized triacylglycerols in hepatic stellate cells.Journal of lipid research · 2016Article
- Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche.BMC veterinary research · 2014Article
- Article
- The two main forms of histiocytic sarcoma in the predisposed Flatcoated retriever dog display variation in gene expression.PloS one · 2014Article
- Congenital multiple intrahepatic portosystemic shunt: an autopsy case.International journal of clinical and experimental pathology · 2014Article
- Gene expression profiling of histiocytic sarcomas in a canine model: the predisposed flatcoated retriever dog.PloS one · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital portosystemic shunts are developmental anomalies of the splanchnic vascular system that cause portal blood to bypass the liver. Large-breed dogs are predisposed for intrahepatic portosystemic shunts (IHPSS) and small-breed dogs for extrahepatic portosystemic shunts (EHPSS). While the phenotype resulting from portal bypass of the liver of the two types of shunt is identical, the genotype and molecular pathways involved are probably different. The aim of this study was to gain insight into the pathways involved in the different types of portosystemic shunting. Microarray analysis of mRNA expression in liver tissue from dogs with EHPSS and IHPSS revealed that the expression of 26 genes was altered in either IHPSS or EHPSS samples compared with that in liver samples from control dogs. Quantitative real-time PCR of these genes in 14 IHPSS, 17 EHPSS, and 8 control liver samples revealed a significant differential expression of ACBP, CCBL1, GPC3, HAMP, PALLD, VCAM1, and WEE1. Immunohistochemistry and Western blotting confirmed an increased expression of VCAM1 in IHPSS but its absence in EHPSS, an increased WEE1 expression in IHPSS but not in EHPSS, and a decreased expression of CCBL1 in both shunt types. Regarding their physiologic functions, these findings may indicate a causative role for VCAM1 in EHPSS [corrected] and WEE1 for IHPSS. CCBL1 could be an interesting candidate to study not yet elucidated aspects in the pathophysiology of hepatic encephalopathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.