ArticlePloS one2013
Comparison of sum absolute QRST integral, and temporal variability in depolarization and repolarization, measured by dynamic vectorcardiography approach, in healthy men and women.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Novel measure of electrical dyssynchrony predicts response in cardiac resynchronization therapy: Results from the SMART-AV Trial.Heart rhythm · 2015Trial
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- Electrical Heterogeneity in Hispanic Background Subpopulations: The HCHS/SOL.JACC. Advances · 2024Article
- Review of Processing Pathological Vectorcardiographic Records for the Detection of Heart Disease.Frontiers in physiology · 2022Review
- Competing risks in patients with primary prevention implantable cardioverter-defibrillators: Global Electrical Heterogeneity and Clinical Outcomes study.Heart rhythm · 2021Article
- Electrocardiogram machine learning for detection of cardiovascular disease in African Americans: the Jackson Heart Study.European heart journal. Digital health · 2021Article
- Spatial distribution of physiologic 12-lead QRS complex.Scientific reports · 2021Article
- Characteristics of Cardiac Memory in Patients with Implanted Cardioverter-defibrillators: The Cardiac Memory with Implantable Cardioverter-defibrillator (CAMI) Study.The Journal of innovations in cardiac rhythm management · 2021Article
- Article
- Global electrical heterogeneity associated with drug-induced torsades de pointes.Heart rhythm · 2021Article
- Changes in global electrical heterogeneity associated with dofetilide, quinidine, ranolazine, and verapamil.Heart rhythm · 2020Article
- Dynamic predictive accuracy of electrocardiographic biomarkers of sudden cardiac death within a survival framework: the Atherosclerosis Risk in Communities (ARIC) study.BMC cardiovascular disorders · 2019Article
- Vectorcardiogram in athletes: The Sun Valley Ski Study.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2019Article
- Importance of the heart vector origin point definition for an ECG analysis: The Atherosclerosis Risk in Communities (ARIC) study.Computers in biology and medicine · 2019Article
- Global Electrical Heterogeneity: Mechanisms and Clinical Significance.Computing in cardiology · 2018Article
- The Reproducibility of Global Electrical Heterogeneity ECG Measurements.Computing in cardiology · 2018Article
- Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study).Journal of the American Heart Association · 2018Article
- Global ECG Measures and Cardiac Structure and Function: The ARIC Study (Atherosclerosis Risk in Communities).Circulation. Arrhythmia and electrophysiology · 2018Article
- Risk Stratification of Sudden Cardiac Death After Acute Myocardial Infarction.The Journal of innovations in cardiac rhythm management · 2018Review
- Dynamic Changes in High-Sensitivity Cardiac Troponin I Are Associated with Dynamic Changes in Sum Absolute QRST Integral on Surface Electrocardiogram in Acute Decompensated Heart Failure.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Observational
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3 authors.
Funding
Abstract
backgroundRecently we showed the predictive value of sum absolute QRST integral (SAI QRST) and repolarization lability for risk stratification of sudden cardiac death (SCD) in heart failure patients. The goal of this study was to compare SAI QRST and metrics of depolarization and repolarization variability in healthy men and women.
methodsOrthogonal ECGs were recorded at rest for 10 minutes in 160 healthy men and women (mean age 39.6±14.6, 80 men). Mean spatial TT' angle, and normalized variances of T loop area, of spatial T vector amplitude, of QT interval and Tpeak-Tend area were measured for assessment of repolarization lability. Normalized variances of spatial QRS vector and QRS loop area characterized variability of depolarization. In addition, variability indices (VI) were calculated to adjust for normalized heart rate variance. SAI QRST was measured as the averaged arithmetic sum of areas under the QRST curve.
resultsMen were characterized by shorter QTc (430.3±21.7 vs. 444.7±22.2 ms; P<0.0001) and larger SAI QRST (282.1±66.7 vs. 204.9±58.5 mV*ms; P<0.0001). Repolarization lability negatively correlated with spatial T vector amplitude. Adjusted by normalized heart rate variance, QT variability index was significantly higher in women than in men (-1.54±0.38 vs. -1.70±0.33; P = 0.017). However, in multivariate logistic regression after adjustment for body surface area, QTc, and spatial T vector amplitude, healthy men had 1.5-3 fold higher probability of having larger repolarization lability, as compared to healthy women (T vector amplitude variability index odds ratio 3.88 (95%CI 1.4-11.1; P = 0.012).
conclusionsHealthy men more likely than women have larger repolarization lability.
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