ArticlePloS one2013
Molecular analysis of Anaplasma phagocytophilum isolated from patients with febrile diseases of unknown etiology in China.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- A Systematic Review on the Occurrence ofPathogens (Basel, Switzerland) · 2025Pooled it
- Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- Unveiling the hidden threats: a review of pathogen diversity and public health risks from bats, rodents, and non-human primates in Zambia (1990-2022).Frontiers in public health · 2024Pooled it
- Trial
- Whole transcriptome analysis reveals differential gene expression associated with Anaplasma phagocytophilum invading HL-60 cells.Parasites & vectors · 2026Article
- Molecular detection and genetic diversity ofFrontiers in microbiology · 2026Article
- Tick-Borne Infectious Diseases in China, 2003-2023.China CDC weekly · 2025Review
- Culture and other direct detection methods to diagnose human granulocytic anaplasmosis.American journal of clinical pathology · 2025Article
- Epidemiological, clinical, and laboratory characteristics of human granulocytic anaplasmosis in North India.Journal of clinical microbiology · 2024Article
- Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia.BMC microbiology · 2023Article
- Current knowledge of vector-borne zoonotic pathogens in Zambia: A clarion call to scaling-up "One Health" research in the wake of emerging and re-emerging infectious diseases.PLoS neglected tropical diseases · 2022Review
- Article
- The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains.Parasites & vectors · 2020Article
- Human granulocytic anaplasmosis in Kinmen, an offshore island of Taiwan.PLoS neglected tropical diseases · 2019Article
- Diagnosis and molecular characteristics of human infections caused by Anaplasma phagocytophilum in South Korea.Journal of microbiology (Seoul, Korea) · 2018Article
- Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia.Acta tropica · 2018Article
- Accuracy of Diagnosis of Human Granulocytic Anaplasmosis in China.Emerging infectious diseases · 2016Article
- Emerging tick-borne infections in mainland China: an increasing public health threat.The Lancet. Infectious diseases · 2015Review
- Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives.Frontiers in cellular and infection microbiology · 2015Review
- Detection and characterization of zoonotic pathogens of free-ranging non-human primates from Zambia.Parasites & vectors · 2014Article
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17 authors at 9 institutions in 1 country.
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Abstract
Although anaplasmosis cases have been nationally identified in China, no human isolates of A. phagocytophilum have been obtained, which limits the analysis of any molecular and genetic contributions to patients' severe clinical manifestations and the study of the bacteria's pathogeneses in China. Given this situation, a joint project was conducted in 2009-2010. A total of 421 febrile cases of unknown etiology were collected and the patients' blood samples were collected for laboratory diagnoses including serologic diagnosis based on the four-fold rise in the anti- A. phagocytophilum IgG titer by indirect micro-immunofluorescence assay (IFA), positive PCR assay and confirmation of A. phagocytophilum DNA and positive culture of A. phagocytophilum and confirmed by amplification and sequencing of the 16S rRNA and ank A genes of the A. phagocytophilum isolates. A total of 570 ticks were collected from the patients' domestic animals (456) and from wild fields (114) for culturing and amplifying and sequencing the 16S rRNA gene of A. phagocytophilum. Phylogenetic analyses were performed on the 16S rRNA and ank A gene sequences of the isolates and the ticks tested in the study. A total of 46 (10.9%) confirmed and 16 (3.8%) probable cases were diagnosed and severe clinical features and higher mortality rates were observed in these Chinese patients. Five isolates were obtained and the 16S rRNA genes of the 5 isolates were conserved but variety for ank A genes. Two human isolates and 1 tick isolate from Shandong Peninsula, where all patients exhibited severe clinical manifestations, were grouped as one clan based on the phylogenetic analyses, while 2 other human isolates were clustered in a second clan. 43.5% of H. longicornis were infected with A. phagocytophilum.The present study is the first to obtain clinical isolates of A. phagocytophilum in China. The diversity of the ank A genes of Chinese isolates will help us to further discern the relationship between the variations in the ank A genes and the severity of the disease's clinical manifestations in China.
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