ReviewDeutsches Arzteblatt international2013
The etiology, diagnosis and prevention of liver cirrhosis: part 1 of a series on liver cirrhosis.
Review in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
94 citing papers in PubMed, 1 synthesis or guideline pooled it, 168 citations in OpenAlex.
- Clinical periodontal and dental findings in liver transplant patients: a systematic review and meta-analysis.British dental journal · 2020Pooled it
- The Association of Dietary Macronutrient Quality and Mortality Among Patients With Liver Cirrhosis: A Prospective Cohort Study.Health science reports · 2026Article
- Blood circulating C228T TERT gene promoter mutation is an independent factor for the prognosis of HBV-related hepatocellular carcinoma.BMC cancer · 2026Article
- Predicting esophageal varices in cirrhosis: diagnostic utility of MR elastography and dynamic contrast-enhanced MRI.Abdominal radiology (New York) · 2026Article
- The effect of the use of proton pump inhibitors (PPI) on complications in patients with cirrhosis.BMC gastroenterology · 2026Article
- The Effects of Flaxseed Consumption on Frailty and Sarcopenia in Patients With Liver Cirrhosis: An Open-Labeled Randomized Controlled Clinical Trial.Food science & nutrition · 2026Article
- Periodontal status and microbial profiles across the clinical spectrum of liver cirrhosis.Journal of oral microbiology · 2026Article
- The Role of Comorbidities in Predicting 12-Month Survival in Patients with Liver Cirrhosis: A Study from Zahedan, Iran.Middle East journal of digestive diseases · 2026Article
- Effects of caffeine supplementation on lipid profile and handgrip strength in cirrhotic patients: a randomized, placebo- controlled, clinical trial.BMC nutrition · 2025Article
- Explainable Artificial Intelligence for Diagnosis and Staging of Liver Cirrhosis Using Stacked Ensemble and Multi-Task Learning.Diagnostics (Basel, Switzerland) · 2025Article
- From Pathophysiology to Practice: Evolving Pharmacological Therapies, Clinical Complications, and Pharmacogenetic Considerations in Portal Hypertension.Metabolites · 2025Review
- Immediate management of a cirrhosis-induced severe pericardial effusion: a case report and review of the literature.Journal of medical case reports · 2025Review
- Prevalence and Correlates of Probable Nonalcoholic Steatohepatitis (NASH) in Pars Cohort Study.Archives of Iranian medicine · 2024Article
- Hepatic Bone Morphogenetic Protein and Activin Membrane-Bound Inhibitor Levels Decline in Hepatitis C but Are Not Associated with Progression of Hepatocellular Carcinoma.Biomedicines · 2024Article
- Article
- Mental health and quality of life in patients with chronic liver disease: a single-center structural equation model.BMC gastroenterology · 2024Article
- Article
- Serum biomarkers for liver fibrosis assessment.Advances in laboratory medicine · 2024Review
- Hepatitis B Virus Infection: A Mini Review.Viruses · 2024Review
- Role of albumin infusion in cirrhosis-associated complications.Clinical and experimental medicine · 2024Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCirrhosis of the liver is the end stage of chronic liver disease. Among the many liver disorders that can lead to cirrhosis, some progress rapidly (years) and others more slowly (decades). In Germany, cirrhosis is often a consequence of fatty liver disease due to alcoholism or other causes, but can also be caused by hepatitis B and hepatitis C. Cirrhosis is more common in overweight persons and smokers. The underlying causes of cirrhosis determine its rate of progression and are the focus of preventive efforts and treatment. The prevalence of cirrhosis in Germany is rising; it now ranks among the top 20 causes of death in the country.
methodsThis article is based on a selective review of pertinent literature, including reviews and current guidelines.
resultsStrictly speaking, cirrhosis is a pathological diagnosis; it is, nevertheless, usually diagnosed clinically, by history, physical examination (e.g., cutaneous signs of liver disease), ancillary testing (e.g., ultrasonography, transient elastography) and laboratory analyses (e,g., APRI, which is the quotient of the GOT concentration and the platelet count). There are no laboratory cutoff values for the diagnosis of cirrhosis. Early detection of chronic liver disease, followed by individually tailored, risk-adapted treatment, is the best way to prevent it. Esophagogastroduodenoscopy can be performed early on to assess the risk of variceal bleeding. In most patients, the progression of fibrosis can be averted by early detection and appropriate treatment.
conclusionScreening for chronic liver disease should include history and physical examination, serum transaminase measurement, upper abdominal ultrasonography, and, in some cases, transient elastography.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.