ReviewDeutsches Arzteblatt international2013
Olfactory dysfunction: common in later life and early warning of neurodegenerative disease.
Review in Deutsches Arzteblatt international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 111 citations in OpenAlex.
- Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger's Versus Healthy Controls: A Cross-Sectional Analysis.Journal of autism and developmental disorders · 2020Trial
- Age-related changes in olfactory function: electrophysiological recordings from the olfactory mucosa and human brain.npj aging · 2026Article
- Olfactory Dysfunction After SARS-CoV-2 Infection in the RECOVER Adult Cohort.JAMA network open · 2025Article
- Factors Associated With Persisting Olfactory Dysfunction After COVID-19.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
- Role and Mechanism of Olfactory Stem Cells in the Treatment of Olfactory Disorders.Stem cells international · 2025Review
- Olfactory Dysfunction and Limbic Hypoactivation in Temporal Lobe Epilepsy.Human brain mapping · 2024Article
- Olfactory dysfunction and its related molecular mechanisms in Parkinson's disease.Neural regeneration research · 2024Review
- Aging and Olfactory Training: A Scoping Review.Innovation in aging · 2024Article
- fNIRS a novel neuroimaging tool to investigate olfaction, olfactory imagery, and crossmodal interactions: a systematic review.Frontiers in neuroscience · 2024Review
- Altered Grey Matter-Brain Healthcare Quotient: Interventions of Olfactory Training and Learning of Neuroplasticity.Life (Basel, Switzerland) · 2023Article
- Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?Life (Basel, Switzerland) · 2023Article
- Post-traumatic olfactory dysfunction: a scoping review of assessment and rehabilitation approaches.Frontiers in neurology · 2023Article
- Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies.JCI insight · 2022Article
- Endocannabinoid-mediated neuromodulation in the main olfactory bulb at the interface of environmental stimuli and central neural processing.The European journal of neuroscience · 2022Review
- Olfactory Bulb DToxins · 2022Article
- Neuroimmunoendocrine Link Between Chronic Kidney Disease and Olfactory Deficits.Frontiers in integrative neuroscience · 2022Review
- Article
- Post-COVID-19 Vaccine Parosmia: A Case Report.Cureus · 2021Article
- Associations of the oral microbiota and Candida with taste, smell, appetite and undernutrition in older adults.Scientific reports · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDisturbances of smell and taste are common. About 5% of the general population have anosmia (absence of the sense of smell). Olfactory dysfunction can markedly impair the quality of life.
methodsReview of pertinent literature retrieved by a selective search.
resultsIn recent years, simple and reliable tests of the sense of smell have been introduced in otorhinolaryngology. Olfactory testing has become a new focus of attention in neurology as well, mainly because many patients with neurodegenerative diseases-including the majority of those with Parkinson's or Alzheimer's disease-have olfactory loss early on in the course of their disorder. Olfactory dysfunction is thus regarded as an early sign of neurodegenerative disease that may allow a tentative diagnosis to be made years before the motor or cognitive disturbances become evident. As for the treatment of olfactory loss, anti-inflammatory drugs and surgery can help in some cases, and olfactory training can lead to significant improvement of post-viral olfactory deficits.
conclusionOlfactory dysfunction is common and becomes more common with advancing age. It is increasingly receiving attention as an important sign for the early diagnosis and the differential diagnosis of neurodegenerative disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.