ArticleG3 (Bethesda, Md.)2013
A mosaic genetic screen for genes involved in the early steps of Drosophila oogenesis.
Article in G3 (Bethesda, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- TORC1-dependent translation drives chromatin remodeling during the germ-cell-to-maternal transition in Drosophila.The EMBO journal · 2026Article
- Myosin VI is expressed in developing ovarian follicles inFrontiers in cell and developmental biology · 2025Article
- The evolution of ovary-biased gene expression in Hawaiian Drosophila.PLoS genetics · 2023Article
- piRNA-independent transposon silencing by the Drosophila THO complex.Developmental cell · 2021Article
- The Dynamic Network of RNP RNase P Subunits.International journal of molecular sciences · 2021Review
- Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity.Developmental cell · 2021Article
- Coordinating Proliferation, Polarity, and Cell Fate in theFrontiers in cell and developmental biology · 2020Review
- Spargel/dPGC-1 is essential for oogenesis and nutrient-mediated ovarian growth in Drosophila.Developmental biology · 2019Article
- Co-dependent Assembly of Drosophila piRNA Precursor Complexes and piRNA Cluster Heterochromatin.Cell reports · 2018Article
- Physiological characterization of the emergence from diapause: A transcriptomics approach.Scientific reports · 2018Article
- Article
- Australian black field crickets show changes in neural gene expression associated with socially-induced morphological, life-history, and behavioral plasticity.BMC genomics · 2016Article
- tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription.The EMBO journal · 2015Article
- Abscission is regulated by the ESCRT-III protein shrub in Drosophila germline stem cells.PLoS genetics · 2015Article
- Discovering Che-1/AATF: a new attractive target for cancer therapy.Frontiers in genetics · 2015Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The first hours of Drosophila embryogenesis rely exclusively on maternal information stored within the egg during oogenesis. The formation of the egg chamber is thus a crucial step for the development of the future adult. It has emerged that many key developmental decisions are made during the very first stages of oogenesis. We performed a clonal genetic screen on the left arm of chromosome 2 for mutations affecting early oogenesis. During the first round of screening, we scored for defects in egg chambers morphology as an easy read-out of early abnormalities. In a second round of screening, we analyzed the localization of centrosomes and Orb protein within the oocyte, the position of the oocyte within the egg chamber, and the progression through meiosis. We have generated a collection of 71 EMS-induced mutants that affect oocyte determination, polarization, or localization. We also recovered mutants affecting the number of germline cyst divisions or the differentiation of follicle cells. Here, we describe the analysis of nine complementation groups and eight single alleles. We mapped several mutations and identified alleles of Bicaudal-D, lethal(2) giant larvae, kuzbanian, GDP-mannose 4,6-dehydratase, tho2, and eiF4A. We further report the molecular identification of two alleles of the Drosophila homolog of Che-1/AATF and demonstrate its antiapoptotic activity in vivo. This collection of mutants will be useful to investigate further the early steps of Drosophila oogenesis at a genetic level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.