ArticleSleep2013
Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The Amygdala: Another Switch That Controls Consciousness?Anesthesiology · 2025Article
- Sex differences in body temperature and neural power spectra in response to repeated restraint stress.Stress (Amsterdam, Netherlands) · 2024Article
- Glutamatergic Neurons in the Preoptic Hypothalamus Promote Wakefulness, Destabilize NREM Sleep, Suppress REM Sleep, and Regulate Cortical Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Sleep-Wake Neurobiology.Advances in experimental medicine and biology · 2021Review
- Connection Input Mapping and 3D Reconstruction of the Brainstem and Spinal Cord Projections to the CSF-Contacting Nucleus.Frontiers in neural circuits · 2020Article
- Orexin Receptor Blockade-Induced Sleep Preserves the Ability to Wake in the Presence of Threat in Mice.Frontiers in behavioral neuroscience · 2018Article
- GABAergic ventrolateral pre‑optic nucleus neurons are involved in the mediation of the anesthetic hypnosis induced by propofol.Molecular medicine reports · 2017Article
- How the cortico-thalamic feedback affects the EEG power spectrum over frontal and occipital regions during propofol-induced sedation.Journal of computational neuroscience · 2015Article
- Study of GABAergic extra-synaptic tonic inhibition in single neurons and neural populations by traversing neural scales: application to propofol-induced anaesthesia.Journal of computational neuroscience · 2014Article
- GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.The European journal of neuroscience · 2014Article
- Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity.Frontiers in systems neuroscience · 2014Article
- Cognitive unbinding: a neuroscientific paradigm of general anesthesia and related states of unconsciousness.Neuroscience and biobehavioral reviews · 2013Review
- GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.Brain research · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
STUDY
objectivesGamma-aminobutyric acid (GABA) causes phasic inhibition via synaptic GABAA receptors and tonic inhibition via extrasynaptic GABAA receptors. GABA levels in the extracellular space regulate arousal state and cognition by volume transmission via extrasynaptic GABAA receptors. GABAergic transmission in the pontine reticular formation promotes wakefulness. No previous studies have determined whether an agonist at extrasynaptic GABAA receptors administered into the pontine reticular formation alters sleep and wakefulness. Therefore, this study used gaboxadol (THIP; agonist at extrasynaptic GABAA receptors that contain a δ subunit) to test the hypothesis that extrasynaptic GABAA receptors within the pontine reticular formation modulate sleep and wakefulness.
designWithin/between subjects.
settingUniversity of Michigan. PATIENTS OR
participantsAdult male Crl:CD*(SD) (Sprague-Dawley) rats (n = 10).
interventionsMicroinjection of gaboxadol, the nonsubtype selective GABAA receptor agonist muscimol (positive control), and saline (negative control) into the rostral pontine reticular formation. MEASUREMENTS AND
resultsGaboxadol significantly increased wakefulness and decreased both nonrapid eye movement sleep and rapid eye movement sleep in a concentration-dependent manner. Relative to saline, gaboxadol did not alter electroencephalogram power. Microinjection of muscimol into the pontine reticular formation of the same rats that received gaboxadol increased wakefulness and decreased sleep.
conclusionTonic inhibition via extrasynaptic GABAA receptors that contain a δ subunit may be one mechanism by which the extracellular pool of endogenous GABA in the rostral pontine reticular formation promotes wakefulness. CITATION: Vanini G; Baghdoyan HA. Extrasynaptic GABAA receptors in rat pontine reticular formation increase wakefulness. SLEEP 2013;36(3):337-343.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.