ReviewMolecular reproduction and development2013
Lessons for inductive germline determination.
Review in Molecular reproduction and development, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- The dynamic evolution of panarthropod germ cell specification mechanisms.Development (Cambridge, England) · 2026Review
- The first embryo, the origin of cancer and animal phylogeny. III. The totipotency as revealed by morphogenesis and the neoplasia controlled by cellular differentiation.Journal of biosciences · 2024Review
- Germ Granules in Animal Oogenesis.Journal of developmental biology · 2022Review
- The first embryo, the origin of cancer and animal phylogeny. I. A presentation of the neoplastic process and its connection with cell fusion and germline formation.Frontiers in cell and developmental biology · 2022Article
- Primordial Germ Cell Specification in Vertebrate Embryos: Phylogenetic Distribution and Conserved Molecular Features of Preformation and Induction.Frontiers in cell and developmental biology · 2021Review
- Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemoneeLife · 2020Article
- Evolving Role of RING1 and YY1 Binding Protein in the Regulation of Germ-Cell-Specific Transcription.Genes · 2019Review
- Gonadal microRNA Expression Profiles and Their Potential Role in Sex Differentiation and Gonadal Maturation of Mud Crab Scylla paramamosain.Marine biotechnology (New York, N.Y.) · 2019Article
- Multiplicity of Buc copies in Atlantic salmon contrasts with loss of the germ cell determinant in primates, rodents and axolotl.BMC evolutionary biology · 2016Article
- Developmental expression of "germline"- and "sex determination"-related genes in the ctenophore Mnemiopsis leidyi.EvoDevo · 2016Article
- Methods to study maternal regulation of germ cell specification in zebrafish.Methods in cell biology · 2016Article
- Global transcriptional repression: An initial and essential step for Plasmodium sexual development.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mitochondrial membrane potential: a trait involved in organelle inheritance?Biology letters · 2015Article
- Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis.Development (Cambridge, England) · 2015Article
- Specifying and protecting germ cell fate.Nature reviews. Molecular cell biology · 2015Review
- The biology of the germ line in echinoderms.Molecular reproduction and development · 2014Review
- Origin and development of the germ line in sea stars.Genesis (New York, N.Y. : 2000) · 2014Review
- Selective accumulation of germ-line associated gene products in early development of the sea star and distinct differences from germ-line development in the sea urchin.Developmental dynamics : an official publication of the American Association of Anatomists · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Formation of the germline in an embryo marks a fresh round of reproductive potential, yet the developmental stage and location within the embryo where the primordial germ cells (PGCs) form differs wildly among species. In most animals, the germline is formed either by an inherited mechanism, in which maternal provisions within the oocyte drive localized germ-cell fate once acquired in the embryo, or an inductive mechanism that involves signaling between cells that directs germ-cell fate. The inherited mechanism has been widely studied in model organisms such as Drosophila melanogaster, Caenorhabditis elegans, Xenopus laevis, and Danio rerio. Given the rapid generation time and the effective adaptation for laboratory research of these organisms, it is not coincidental that research on these organisms has led the field in elucidating mechanisms for germline specification. The inductive mechanism, however, is less well understood and is studied primarily in the mouse (Mus musculus). In this review, we compare and contrast these two fundamental mechanisms for germline determination, beginning with the key molecular determinants that play a role in the formation of germ cells across all animal taxa. We next explore the current understanding of the inductive mechanism of germ-cell determination in mice, and evaluate the hypotheses for selective pressures on these contrasting mechanisms. We then discuss the hypothesis that the transition between these determination mechanisms, which has happened many times in phylogeny, is more of a continuum than a binary change. Finally, we propose an analogy between germline determination and sex determination in vertebrates-two of the milestones of reproduction and development-in which animals use contrasting strategies to activate similar pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.