SynthesisThe Cochrane database of systematic reviews2013
Hypothermia for neuroprotection in children after cardiopulmonary arrest.
Synthesis in The Cochrane database of systematic reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews.The Cochrane database of systematic reviews · 2018Pooled it
- Therapeutic hypothermia after out-of-hospital cardiac arrest in children.The New England journal of medicine · 2015Trial
- Hydrogen ventilation combined with mild hypothermia improves short-term neurological outcomes in a 5-day neonatal hypoxia-ischaemia piglet model.Scientific reports · 2019Article
- The Big Black Brain: Subdural Hemorrhage with Hemispheric Swelling and Low Attenuation.Journal of child & adolescent trauma · 2018Article
- Hypothermia Reduces Mortality, Prevents the Calcium Plateau, and Is Neuroprotective Following Status Epilepticus in Rats.Frontiers in neurology · 2018Article
- Potential and Limitations of Cochrane Reviews in Pediatric Cardiology: A Systematic Analysis.Pediatric cardiology · 2017Review
- Article
- Cardiorespiratory arrest in children (out of hospital).BMJ clinical evidence · 2015Article
- A mechanistic investigation of the oxygen fixation hypothesis and oxygen enhancement ratio.Biomedical physics & engineering express · 2015Article
- Targeted Temperature Management in Pediatric Central Nervous System Disease.Current treatment options in pediatrics · 2015Article
- Selective head cooling for the treatment of neurologic complications of acute liver failure in a newborn with disseminated herpes infection.SpringerPlus · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiopulmonary arrest in paediatric patients often results in death or survival with severe brain injury. Therapeutic hypothermia, lowering of the core body temperature to 32°C to 34°C, may reduce injury to the brain in the period after the circulation has been restored. This therapy has been effective in neonates with hypoxic ischaemic encephalopathy and adults after witnessed ventricular fibrillation cardiopulmonary arrest. The effect of therapeutic hypothermia after cardiopulmonary arrest in paediatric patients is unknown.
objectivesTo assess the clinical effectiveness of therapeutic hypothermia after paediatric cardiopulmonary arrest. SEARCH
methodsWe searched the Cochrane Anaesthesia Review Group Specialized Register; Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2011, Issue 11); Ovid MEDLINE (1966 to December 2011); Ovid EMBASE (1980 to December 2011); Ovid CINAHL (1982 to December 2011); Ovid BIOSIS (1923 to December 2011); and Web of Science (1945 to December 2011). We searched the trials registry databases for ongoing trials. We also contacted international experts in therapeutic hypothermia and paediatric critical care to locate further published and unpublished studies. SELECTION CRITERIA: We planned to include randomized and quasi-randomized controlled trials comparing therapeutic hypothermia with normothermia or standard care in children, aged 24 hours to 18 years, after paediatric cardiopulmonary arrest. DATA COLLECTION AND ANALYSIS: Two authors independently assessed articles for inclusion. MAIN
resultsWe found no studies that satisfied the inclusion criteria. We found four on-going randomized controlled trials which may be available for analysis in the future. We excluded 18 non-randomized studies. Of these 18 non-randomized studies, three compared therapeutic hypothermia with standard therapy and demonstrated no difference in mortality or the proportion of children with a good neurological outcome; a narrative report was presented. AUTHORS'
conclusionsBased on this review, we are unable to make any recommendations for clinical practice. Randomized controlled trials are needed and the results of on-going trials will be assessed when available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.