SynthesisThe Cochrane database of systematic reviews2013
Antibiotics for mastitis in breastfeeding women.
Synthesis in The Cochrane database of systematic reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- Interventions for preventing mastitis after childbirth.The Cochrane database of systematic reviews · 2020Pooled it
- Treatments for breast abscesses in breastfeeding women.The Cochrane database of systematic reviews · 2015Pooled it
- Study protocol: evaluation of the probiotic Lactobacillus Fermentum CECT5716 for the prevention of mastitis in breastfeeding women: a randomised controlled trial.BMC pregnancy and childbirth · 2017Trial
- Non-pharmacological interventions for lactational mastitis: a systematic review and meta-analysis protocol.BMJ open · 2026Article
- Management of Mastitis in the Hospital Setting: An International Audit Study.Journal of human lactation : official journal of International Lactation Consultant Association · 2025Article
- Whole-genome sequencing of bacteria accountable for lactational mastitis in humans combined with an examination of their antibiotic resistance profiles.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Emergency department use in the postpartum period: a retrospective cohort study.Research square · 2024Article
- Article
- Predictive Risk Factors for Childbirth-Associated Breast Infections in the United States: A 10-Year Perspective.International journal of environmental research and public health · 2023Article
- Therapeutic potential of natural products and antibiotics against bovine mastitis pathogen of cows and buffaloes.Veterinarni medicina · 2023Article
- Impact of the National Action Plan for Antimicrobial Resistance on Antibiotic Use for Mastitis Using a Japanese Nationwide Database.Breast care (Basel, Switzerland) · 2023Article
- Lactation breast abscess treated with Gualou Xiaoyong decoction and painless lactation manipulation: A case report and review of literature.World journal of clinical cases · 2023Article
- Breastmilk microbiome changes associated with lactational mastitis and treatment with dandelion extract.Frontiers in microbiology · 2023Article
- Increased risk of postpartum depression in women with lactational mastitis: a cross-sectional study.Frontiers in psychiatry · 2023Article
- Breast Pumps and Mastitis in Breastfeeding Women: Clarifying the Relationship.Frontiers in pediatrics · 2022Article
- Article
- Mucosal Immunity and Liver Metabolism in the Complex Condition of Lactation Insufficiency.Journal of human lactation : official journal of International Lactation Consultant Association · 2020Article
- Bacterial Biofilm and its Role in the Pathogenesis of Disease.Antibiotics (Basel, Switzerland) · 2020Review
- Surgical drainage of lactational breast abscess with ultrasound-guided Encor vacuum-assisted breast biopsy system.The breast journal · 2019Article
- The microbiology and treatment of human mastitis.Medical microbiology and immunology · 2018Review
Corrections and comments
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- Update of
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMastitis can be caused by ineffective positioning of the baby at the breast or restricted feeding. Infective mastitis is commonly caused by Staphylococcus aureus. The prevalence of mastitis in breastfeeding women may reach 33%. Effective milk removal, pain medication and antibiotic therapy have been the mainstays of treatment.
objectivesThis review aims to examine the effectiveness of antibiotic therapies in relieving symptoms for breastfeeding women with mastitis with or without laboratory investigation. SEARCH
methodsWe searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2012), contacted investigators and other content experts known to us for unpublished trials and scanned the reference lists of retrieved articles. SELECTION CRITERIA: We selected randomised controlled trials (RCTs) and quasi-RCTs comparing the effectiveness of various types of antibiotic therapies or antibiotic therapy versus alternative therapies for the treatment of mastitis. DATA COLLECTION AND ANALYSIS: Two review authors independently assessed trial quality and extracted data. When in dispute, we consulted a third author. MAIN
resultsTwo trials met the inclusion criteria. One small trial (n = 25) compared amoxicillin with cephradine and found no significant difference between the two antibiotics in terms of symptom relief and abscess formation. Another, older study compared breast emptying alone as 'supportive therapy' versus antibiotic therapy plus supportive therapy, and no therapy. The findings of the latter study suggested faster clearance of symptoms for women using antibiotics, although the study design was problematic. AUTHORS'
conclusionsThere is insufficient evidence to confirm or refute the effectiveness of antibiotic therapy for the treatment of lactational mastitis. There is an urgent need to conduct high-quality, double-blinded RCTs to determine whether antibiotics should be used in this common postpartum condition.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.