Evidence map›Paper›PMID 23450245›Full record

ReviewNatural product reports2013

21st century natural product research and drug development and traditional medicines.

Linh T Ngo, Joseph I Okogun, William R Folk

Abstract readHistorical ArticleReview
In one paragraph

Review in Natural product reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Electrospun Nanofibers Loaded withPharmaceuticals (Basel, Switzerland) · 2026
    Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Recent Advancements in the Analyses of Natural Products.Combinatorial chemistry & high throughput screening · 2025
    Review
  9. Review
  10. Vasorelaxant and Hypotensive Effects ofInternational journal of molecular sciences · 2024
    Article
  11. Article
  12. The effects and mechanisms of natural products onFrontiers in cellular and infection microbiology · 2024
    Review
  13. Antinociceptive Effect ofLife (Basel, Switzerland) · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
  18. Review
  19. Review
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linh T NgoGenetics Area Program, University of Missouri, Columbia, MO 65211, USA.
Joseph I Okogun
William R Folk

Funding

The Interactions Core/Mark McintoshP50AT006273 · NCCIH · UNIVERSITY OF MISSOURI-COLUMBIA · PI LUBAHN, DENNIS B · 2010 to 2014
$7.4M
TICIPS: HIV/AIDS, Secondary Infections and Immune ModulationU19AT003264 · NCCIH · UNIVERSITY OF MISSOURI-COLUMBIA · PI FOLK, WILLIAM ROBERT · 2005 to 2010
$4.5M
NCCIH NIH HHS 3U19AT003264NCCIH NIH HHS P50 AT006273NCCIH NIH HHS P50AT006273NCCIH NIH HHS U19 AT003264
6 · The paper itself

Abstract

Natural products and related structures are essential sources of new pharmaceuticals, because of the immense variety of functionally relevant secondary metabolites of microbial and plant species. Furthermore, the development of powerful analytical tools based upon genomics, proteomics, metabolomics, bioinformatics and other 21st century technologies are greatly expediting identification and characterization of these natural products. Here we discuss the synergistic and reciprocal benefits of linking these 'omics technologies with robust ethnobotanical and ethnomedical studies of traditional medicines, to provide critically needed improved medicines and treatments that are inexpensive, accessible, safe and reliable. However, careless application of modern technologies can challenge traditional knowledge and biodiversity that are the foundation of traditional medicines. To address such challenges while fulfilling the need for improved (and new) medicines, we encourage the development of Regional Centres of 'omics Technologies functionally linked with Regional Centres of Genetic Resources, especially in regions of the world where use of traditional medicines is prevalent and essential for health.

Indexed as

Biological ProductsAntimalarialsAntitubercular AgentsDrug DiscoveryHistory, 21st CenturyMedicine, TraditionalMolecular StructurePlant PreparationsPlants, MedicinalAntimalarialsAntitubercular AgentsBiological ProductsPlant Preparations

Identifiers

PMID23450245
PMCPMC3652390

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.