ArticleAllergy, asthma & immunology research2013
Clinical predictors of primary immunodeficiency diseases in children.
Article in Allergy, asthma & immunology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 77 citations in OpenAlex.
- International survey on immunological diagnostics in children with sepsis.Intensive care medicine. Paediatric and neonatal · 2026Article
- Early Clinical Warning Signs of Inborn Errors of Immunity in the Neonatal Intensive Care Unit: A Retrospective Observational Study.Sisli Etfal Hastanesi tip bulteni · 2026Article
- Major Histocompatibility Complex Class II Deficiency Beyond Infancy.Case reports in immunology · 2025Article
- Development of an Expert-Based Scoring System for Early Identification of Patients with Inborn Errors of Immunity in Primary Care Settings - the PIDCAP Project.Journal of clinical immunology · 2024Article
- Electronic health record signatures identify undiagnosed patients with common variable immunodeficiency disease.Science translational medicine · 2024Article
- Antibody deficiencies in children are associated with prematurity and a family history of infections.Pediatric research · 2023Article
- Genetic screening in a Brazilian cohort with inborn errors of immunity.BMC genomic data · 2023Article
- Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
- Extended List of Warning Signs in Qualification to Diagnosis and Treatment of Inborn Errors of Immunity in Children and Young Adults.Journal of clinical medicine · 2023Article
- Genetic diagnosis of inborn errors of immunity using clinical exome sequencing.Frontiers in immunology · 2023Article
- Evaluation of the 10 Warning Signs in Primary and Secondary Immunodeficient Patients.Frontiers in immunology · 2022Article
- Awareness of primary immunodeficiency diseases at a national pediatric reference center in Peru.Einstein (Sao Paulo, Brazil) · 2021Article
- Analysis of scoring systems for primary immunodeficiency diagnosis in adult immunology clinics.Clinical and experimental immunology · 2021Article
- Severe combined immunodeficiency: a case series from a paediatric hospital in Kenya.The Pan African medical journal · 2021Article
- A novel mutation in RFXANK gene and low B cell count in a patient with MHC class II deficiency: a case report.Immunologic research · 2020Article
- The Unique Disease Course of Children with Very Early onset-Inflammatory Bowel Disease.Inflammatory bowel diseases · 2020Article
- Primary Immunodeficiency Disorders Among North Indian Children.Indian journal of pediatrics · 2019Article
- Targeted screening for primary immunodeficiency disorders in the neonatal period and early infancy.African health sciences · 2019Article
- The burden of common variable immunodeficiency disorders: a retrospective analysis of the European Society for Immunodeficiency (ESID) registry data.Orphanet journal of rare diseases · 2018Article
- Complications Associated with Underweight Primary Immunodeficiency Patients: Prevalence and Associations Within the USIDNET Registry.Journal of clinical immunology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo promote awareness of primary immunodeficiency (PID), the "10 warning signs" of PID and an immunodeficiency-related (IDR) score were developed. However, their efficiency in identifying PID cases was not sufficiently evaluated in clinical practice. The objective of this study was to test the validity of the 10 warning signs and IDR score in identifying PID among children with recurrent infections at a tertiary pediatric hospital in Egypt.
methodsA retrospective analysis of the medical records of 204 patients was performed. Of these patients, 92 had defined PID diseases and 112 were considered non-PID cases because investigations were inconclusive.
resultsDemonstrating two warning signs and an IDR score of 6 led to sensitivities of 94 and 66%, respectively, and specificities of 64 and 75%, respectively, in identifying PID cases. The strongest predictor of PID was family history that, if combined with the need for intravenous antibiotics, recurrent deep-seated infections, and failure to thrive, could identify 81% of PID patients. A family history of PID, sibling death, and/or parental consanguinity would predict 92% of combined immunodeficiencies, 92% of phagocyte defects, 87% of well-identified immunodeficiency syndromes, and 84% of antibody deficiency if the need for intravenous antibiotics is considered in the latter.
conclusionsThe 10 warning signs and IDR score do not aid in an early diagnosis of severe PID. Educational campaigns should target pediatricians aiming to increase PID awareness and to address family history of PID, parental consanguinity, and previous sibling death as key predictors of PID in communities with a high prevalence of consanguineous marriages.
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