ArticleRadiology and oncology2013
Tumor size and effectiveness of electrochemotherapy.
Article in Radiology and oncology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of skin-directed therapy for cutaneous metastases from advanced cancer: a meta-analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Pooled it
- Electrochemotherapy treatment of locally advanced and metastatic soft tissue sarcomas: results of a non-comparative phase II study.World journal of surgery · 2014Trial
- Outcome of dogs with low- and high-grade mast cell tumors treated with electrochemotherapy.Journal of veterinary internal medicine · 2026Article
- Effect of Bleomycin Hydrolase Expression in Tumor Tissue on the Therapeutic Effectiveness of Electrochemotherapy.Cancers · 2025Article
- Quality of life changes after electrochemotherapy: a prospective single-center analysis.Scientific reports · 2025Article
- Article
- Veterinary Guidelines for Electrochemotherapy of Superficial Tumors.Frontiers in veterinary science · 2022Article
- Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute.Current oncology (Toronto, Ont.) · 2021Article
- A Retrospective Multicentric Study of Electrochemotherapy in the Treatment of Feline Nasal Planum Squamous Cell Carcinoma.Veterinary sciences · 2021Article
- A Prospective Phase II Study Evaluating Intraoperative Electrochemotherapy of Hepatocellular Carcinoma.Cancers · 2020Article
- Comparison of two different doses of bleomycin in electrochemotherapy protocols for feline cutaneous squamous cell carcinoma nonsegregated from ultraviolet light exposure.Scientific reports · 2020Article
- Electroporation-Based Treatments in Small Animal Veterinary Oral and Maxillofacial Oncology.Frontiers in veterinary science · 2020Review
- Electrochemotherapy of radioresistant head and neck squamous cell carcinoma cells and tumor xenografts.Oncology reports · 2019Article
- Electrochemotherapy as a New Modality in Interventional Oncology: A Review.Technology in cancer research & treatment · 2018Review
- Treatment of lymph node metastases from gastric cancer with a combination of Irreversible Electroporation and Electrochemotherapy: a case report.Clinical case reports · 2017Article
- Basal cell carcinoma: 10-year experience with electrochemotherapy.Journal of translational medicine · 2017Observational
- Electrochemotherapy efficacy evaluation for treatment of locally advanced stage III cutaneous squamous cell carcinoma: a 22-cases retrospective analysis.Journal of translational medicine · 2017Article
- Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats.Journal of visualized experiments : JoVE · 2016Article
- Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality.Radiology and oncology · 2016Article
- Recommendations for improving the quality of reporting clinical electrochemotherapy studies based on qualitative systematic review.Radiology and oncology · 2016Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundElectrochemotherapy (ECT) is an effective and safe method for local treatment of tumors. However, relatively large variability in effectiveness of ECT has been observed, which likely results from different treatment conditions and tumor characteristics. The aim of this study was to investigate the relationship between tumor size and effectiveness of a single-session ECT. MATERIALS AND
methodsA systematic search of various bibliographic databases was performed and nine studies eligible for this study were extracted. Different statistical methods including meta-analysis were applied to analyze the data.
resultsThe results of analysis based on data from 1466 tumors of any histotype show significantly lower effectiveness of ECT on tumors with maximal diameter equal to or larger than 3 cm (complete response (CR) of 33.3%, objective response (OR) of 68.2%) in comparison to smaller tumors (CR% of 59.5%, OR% of 85.7%). The results of meta-analysis indicated that ECT performed on tumors smaller than 3 cm statistically significantly increases the probability of CR by 31.0% and OR by 24.9% on average in comparison to larger tumors. The analysis of raw data about the size and response of tumors showed statistically significant decrease in effectiveness of ECT progressively with increasing tumor diameter. The biggest drop in CR% was detected at tumor diameters as small as 2 cm.
conclusionsThe standard operating procedures for ECT should be reexamined and refined for the treatment of large tumors. We propose that future clinical trials should include accurate ECT treatment planning and/or multiple ECT cycles, besides a prolonged observation for tumor response evaluation.
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