ArticleInternational journal of nanomedicine2013
Short communication: Carboxylate functionalized superparamagnetic iron oxide nanoparticles (SPION) for the reduction of S. aureus growth post biofilm formation.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 47 citations in OpenAlex.
- Staphylococcal Drug Resistance: Mechanisms, Therapies, and Nanoparticle Interventions.Infection and drug resistance · 2025Review
- Fimbria targeting superparamagnetic iron oxide nanoparticles enhance the antimicrobial and antibiofilm activity of ciprofloxacin against quinolone-resistant E. coli.Microbial biotechnology · 2023Article
- Molecular dynamics simulation on surface modification of quantum scaled CuO nano-clusters to support their experimental studies.Scientific reports · 2022Article
- Review
- Nanomaterials for Treating Bacterial Biofilms on Implantable Medical Devices.Nanomaterials (Basel, Switzerland) · 2020Review
- Metal Oxide Nanoparticles Against Bacterial Biofilms: Perspectives and Limitations.Microorganisms · 2020Review
- Magnetic Nanosystems as a Therapeutic Tool to Combat Pathogenic Fungi.Advanced pharmaceutical bulletin · 2020Review
- Nano-Strategies to Fight Multidrug Resistant Bacteria-"A Battle of the Titans".Frontiers in microbiology · 2018Review
- Bactericidal and immunomodulatory properties of magnetic nanoparticles functionalized by 1,4-dihydropyridines.International journal of nanomedicine · 2018Article
- Formulation and candidacidal activity of magnetic nanoparticles coated with cathelicidin LL-37 and ceragenin CSA-13.Scientific reports · 2017Article
- The antimicrobial activity of nanoparticles: present situation and prospects for the future.International journal of nanomedicine · 2017Review
- Article
- Bactericidal activity and biocompatibility of ceragenin-coated magnetic nanoparticles.Journal of nanobiotechnology · 2015Article
- Antimicrobial properties of nanomolecules: potential candidates as antibiotics in the era of multi-drug resistance.Epidemiology and health · 2015Review
- Gold-functionalized magnetic nanoparticles restrict growth of Pseudomonas aeruginosa.International journal of nanomedicine · 2014Article
- Core-shell magnetic nanoparticles display synergistic antibacterial effects againstInternational journal of nanomedicineArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilms formed by antibiotic resistant Staphylococcus aureus (S. aureus) continue to be a problem for medical devices. Antibiotic resistant bacteria (such as S. aureus) often complicate the treatment and healing of the patient, yet, medical devices are needed to heal such patients. Therefore, methods to treat these Biofilms once formed on medical devices are badly needed. Due to their small size and magnetic properties, superparamagnetic iron oxide nanoparticles (SPION) may be one possible material to penetrate Biofilms and kill or slow the growth of bacteria. In this study, SPION were functionalized with amine, carboxylate, and isocyanate functional groups to further improve their efficacy to disrupt the growth of S. aureus Biofilms. Without the use of antibiotics, results showed that SPION functionalized with carboxylate groups (followed by isocyanate then amine functional groups then unfunctionalized SPION) significantly disrupted Biofilms and retarded the growth of S. aureus compared to untreated Biofilms (by over 35% after 24 hours).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.