ArticleJournal of children's orthopaedics2012
Changing pattern of femoral fractures in osteogenesis imperfecta with prolonged use of bisphosphonates.
Article in Journal of children's orthopaedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 56 citations in OpenAlex.
- Operatively Treated Pelvic Ring Fractures in Adult Patient with Osteogenesis Imperfecta after Traumatic Injury: A Case Report.Hawai'i journal of health & social welfare · 2026Article
- The administration of exogenous HSP47 as a collagen-specific therapeutic approach.JCI insight · 2025Article
- Skeletal outcomes of patients with osteogenesis imperfecta during drug holiday of bisphosphonates: a real-world study.Frontiers in endocrinology · 2022Article
- Inhibition of TGF-β Increases Bone Volume and Strength in a Mouse Model of Osteogenesis Imperfecta.JBMR plus · 2021Article
- Incidence and treatment of adult femoral fractures with osteogenesis imperfecta: An analysis of a center of 72 patients in Taiwan.International journal of medical sciences · 2021Article
- Incidence and treatment of femur fractures in adults with osteogenesis imperfecta: an analysis of an expert clinic of 216 patients.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Article
- Developments in rare bone diseases and mineral disorders.Therapeutic advances in chronic disease · 2018Review
- Review
- Femoral neck fractures in osteogenesis imperfecta treated with bisphosphonates.Journal of children's orthopaedics · 2017Article
- A Subtrochanteric Femoral Stress Fracture following Bisphosphonate Treatment in an Adolescent Girl.Hormone research in paediatrics · 2017Article
- Article
- Pamidronate affects the mandibular cortex of children with osteogenesis imperfecta.Journal of dental research · 2015Article
- Recent developments in osteogenesis imperfecta.F1000Research · 2015Review
- Rare bone diseases and their dental, oral, and craniofacial manifestations.Journal of dental research · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOsteogenesis imperfecta (OI) has been treated with bisphosphonates for many years, with some clear clinical benefits. In adults, there are reports of a new pattern of atraumatic subtrochanteric fractures with bisphosphonate treatment. This study assesses if bisphosphonate treatment leads to an altered pattern of femoral fractures.
methodsRetrospective review of imaging for a cohort of 176 bisphosphonate-treated OI patients to identify the locations of femoral fractures over a two-year period, as compared to a historical control group managed pre-bisphosphonates.
resultsSixteen femoral fractures were identified in this time period in the bisphosphonate-treated group. All but two were within the subtrochanteric region. In comparison, the historical group-composed of 26 femoral fractures-had a more widespread fracture pattern, with the most frequent location being the mid-diaphysis. Many of the subtrochanteric fractures in the treatment group occurred with minimal trauma.
conclusionsIt appears that concerns over the treatment of the adult osteoporotic population with bisphosphonates are amplified and mirrored in OI. It is possible that the high bending moments in the proximal femur together with altered mechanical properties of cortical bone secondary to the use of this group of drugs increase the risk of this type of injury, which warrants further modification of surgical management of the femur.
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