ArticleThe Journal of biological chemistry2013
The ubiquitin-fold modifier 1 (Ufm1) cascade of Caenorhabditis elegans.
Article in The Journal of biological chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Aging-associated modulation of UFMylation impairs proteostasis in C. elegans.Nature communications · 2026Article
- Mono-UFMylation promotes misfolding-associated secretion of α-synuclein.Science advances · 2024Article
- Down-regulated expression of CDK5RAP3 and UFM1 suggests a poor prognosis in gastric cancer patients.Frontiers in oncology · 2022Article
- Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging.Aging cell · 2020Article
- UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling.Journal of experimental & clinical cancer research : CR · 2019Article
- Genome Scans Reveal Homogenization and Local Adaptations in Populations of the Soybean Cyst Nematode.Frontiers in plant science · 2018Article
- Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence.Scientific reports · 2017Article
- Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.American journal of human genetics · 2016Article
- Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy.American journal of human genetics · 2016Article
- UFMylation: A Unique & Fashionable Modification for Life.Genomics, proteomics & bioinformatics · 2016Review
- Article
- Multifunctional Thioredoxin-Like Protein from the Gastrointestinal Parasitic NematodesJournal of parasitology research · 2016Article
- RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis.Cell death and differentiation · 2015Article
- NeuCode Labeling in Nematodes: Proteomic and Phosphoproteomic Impact of Ascaroside Treatment in Caenorhabditis elegans.Molecular & cellular proteomics : MCP · 2015Article
- Genomic regulation of senescence and innate immunity signaling in the retinal pigment epithelium.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Mechanistic study of Uba5 enzyme and the Ufm1 conjugation pathway.The Journal of biological chemistry · 2014Article
- Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex.Acta crystallographica. Section F, Structural biology communications · 2014Article
- The ufm1 cascade.Cells · 2014Article
- Characterization, crystallization and preliminary X-ray crystallographic analysis of the Uba5 fragment necessary for high-efficiency activation of Ufm1.Acta crystallographica. Section F, Structural biology communications · 2014Article
- An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.PLoS genetics · 2014Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ufm1 (ubiquitin-fold modifier 1) is the most recently identified member of the ubiquitin-like protein family. We characterized the Ufm1 cascade of the model organism Caenorhabditis elegans in terms of function and analyzed interactions of the involved proteins in vitro and in vivo. Furthermore, we investigated the phenotypes of the deletion mutants uba5(ok3364) (activating enzyme of Ufm1) and ufc1(tm4888) (conjugating enzyme of Ufm1). The viable deletion mutants showed a decrease in reproduction, development, life span, and a reduced survival under heavy metal stress. However, an increased survival rate under pathogenic, oxidative, heat, and endoplasmic reticulum stress was observed. We propose that the Ufm1 cascade negatively regulates the IRE1-mediated unfolded protein response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.