ArticleSleep2013
The microarchitecture of C. elegans behavior during lethargus: homeostatic bout dynamics, a typical body posture, and regulation by a central neuron.
Article in Sleep, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
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- The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans.Current biology : CB · 2025Article
- Quiescence Enhances Survival during Viral Infection inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Exploring diabesity pathophysiology through proteomic analysis usingFrontiers in endocrinology · 2024Article
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- A sleep-active neuron can promote survival while sleep behavior is disturbed.PLoS genetics · 2023Article
- High-throughput submicron-resolution microscopy ofiScience · 2023Article
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- Intracellular CaiScience · 2022Article
- Inferring temporal organization of postembryonic development from high-content behavioral tracking.Developmental biology · 2021Article
- Sleep Analysis in AdultThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Behavioral States.Genetics · 2020Review
- RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.Scientific reports · 2020Article
- A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress.Scientific reports · 2020Article
- A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep.PLoS biology · 2020Article
- A microfluidic-induced C. elegans sleep state.Nature communications · 2019Article
- Genetic sleep deprivation: using sleep mutants to study sleep functions.EMBO reports · 2019Review
- Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal inGenetics · 2018Article
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6 authors.
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Abstract
STUDY
objectivesThe nematode C. elegans develops through four larval stages before it reaches adulthood. At the transition between stages and before it sheds its cuticle, it exhibits a sleep-like behavior during a stage termed lethargus. The objectives of this study were to characterize in detail behavioral patterns and physiological activity of a command interneuron during lethargus. MEASUREMENTS AND
resultsWe found that lethargus behavior was composed of bouts of quiescence and motion. The duration of individual bouts ranged from 2 to 100 seconds, and their dynamics exhibited local homeostasis: the duration of bouts of quiescence positively correlated with the duration of bouts of motion that immediately preceded them in a cAMP-dependent manner. In addition, we identified a characteristic body posture during lethargus: the average curvature along the body of L4 lethargus larvae was lower than that of L4 larvae prior to lethargus, and the positions of body bends were distributed non-uniformly along the bodies of quiescent animals. Finally, we found that the AVA interneurons, a pair of backward command neurons, mediated locomotion patterns during L4 lethargus in similar fashion to their function in L4 larvae prior to lethargus. Interestingly, in both developmental stages backward locomotion was initiated and terminated asymmetrically with respect to AVA intraneuronal calcium concentration.
conclusionsThe complex behavioral patterns during lethargus can be dissected to quantifiable elements, which exhibit rich temporal dynamics and are actively regulated by the nervous system. Our findings support the identification of lethargus as a sleep-like state. CITATION: Iwanir S; Tramm N; Nagy S; Wright C; Ish D; Biron D. The microarchitecture of C. elegans behavior during lethargus: homeostatic bout dynamics, a typical body posture, and regulation by a central neuron. SLEEP 2013;36(3):385-395.
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