ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Inhibition of hydrogen sulfide restores normal breathing stability and improves autonomic control during experimental heart failure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 49 citations in OpenAlex.
- Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy.The European respiratory journal · 2018Trial
- The Role of Hydrogen Sulfide in Peripheral Nervous System Modulation.Handbook of experimental pharmacology · 2026Review
- The cystathionine-γ-lyase inhibitor DL-propargylglycine augments the ability of L-cysteine ethyl ester to overcome the adverse effects of morphine on breathing.American journal of physiology. Lung cellular and molecular physiology · 2025Article
- Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders.The Journal of physiology · 2025Review
- Commonalities and differences in carotid body dysfunction in hypertension and heart failure.The Journal of physiology · 2023Article
- Autonomic and respiratory consequences of altered chemoreflex function: clinical and therapeutic implications in cardiovascular diseases.European journal of heart failure · 2023Review
- P2X3 receptor antagonism attenuates the progression of heart failure.Nature communications · 2023Article
- Regulation of Coronary Blood Flow by the Carotid Body Chemoreceptors in Ovine Heart Failure.Frontiers in physiology · 2021Article
- Translating carotid body function into clinical medicine.The Journal of physiology · 2018Review
- Time-Gated Detection of Cystathionine γ-Lyase Activity and Inhibition with a Selective, Luminogenic Hydrogen Sulfide Sensor.Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Contribution of peripheral and central chemoreceptors to sympatho-excitation in heart failure.The Journal of physiology · 2017Review
- Pharmacological targeting of mitochondrial reactive oxygen species counteracts diaphragm weakness in chronic heart failure.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease.Biological research · 2016Review
- Peripheral reflex feedbacks in chronic heart failure: Is it time for a direct treatment?World journal of cardiology · 2015Article
- Hydrogen sulfide and hypoxia-induced changes in TASK (K2P3/9) activity and intracellular Ca(2+) concentration in rat carotid body glomus cells.Respiratory physiology & neurobiology · 2015Article
- Hydrogen sulfide as an oxygen sensor.Antioxidants & redox signaling · 2015Review
- Selective carotid body ablation in experimental heart failure: a new therapeutic tool to improve cardiorespiratory control.Experimental physiology · 2015Review
- Mechanisms of carotid body chemoreflex dysfunction during heart failure.Experimental physiology · 2015Review
- Relevance of the Carotid Body Chemoreflex in the Progression of Heart Failure.BioMed research international · 2015Review
- Pathophysiology of human ventilatory control.The European respiratory journal · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular autonomic imbalance and breathing instability are major contributors to the progression of heart failure (CHF). Potentiation of the carotid body (CB) chemoreflex has been shown to contribute to these effects. Hydrogen sulfide (H2S) recently has been proposed to mediate CB hypoxic chemoreception. We hypothesized that H2S synthesis inhibition should decrease CB chemoreflex activation and improve breathing stability and autonomic function in CHF rats. Using the irreversible inhibitor of cystathione γ-lyase dl-propargylglycine (PAG), we tested the effects of H2S inhibition on resting breathing patterns, the hypoxic and hypercapnic ventilatory responses, and the hypoxic sensitivity of CB chemoreceptor afferents in rats with CHF. In addition, heart rate variability (HRV) and systolic blood pressure variability (SBPV) were calculated as an index of autonomic function. CHF rats, compared with sham rats, exhibited increased breath interval variability and number of apneas, enhanced CB afferent discharge and ventilatory responses to hypoxia, decreased HRV, and increased low-frequency SBPV. Remarkably, PAG treatment reduced the apnea index by 90%, reduced breath interval variability by 40-60%, and reversed the enhanced hypoxic CB afferent and chemoreflex responses observed in CHF rats. Furthermore, PAG treatment partially reversed the alterations in HRV and SBPV in CHF rats. Our results show that PAG treatment restores breathing stability and cardiac autonomic function and reduces the enhanced ventilatory and CB chemosensory responses to hypoxia in CHF rats. These results support the idea that PAG treatment could potentially represent a novel pathway to control sympathetic outflow and breathing instability in CHF.
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Registered trials
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