ArticleProceedings of the National Academy of Sciences of the United States of America2013
Task-related "cortical" bursting depends critically on basal ganglia input and is linked to vocal plasticity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 78 citations in OpenAlex.
- Alpha-synuclein overexpression reduces neural activity within a basal ganglia vocal nucleus in a zebra finch model.PloS one · 2026Article
- Sharp Waves, Bursts, and Coherence: Activity in a Songbird Vocal Circuit Is Influenced by Behavioral State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- An anatomical substrate of credit assignment in reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior.Neurobiology of aging · 2025Article
- Millisecond-scale motor coding precedes sensorimotor learning in songbirds.bioRxiv : the preprint server for biology · 2024Article
- Daily singing of adult songbirds functions to maintain song performance independently of auditory feedback and age.Communications biology · 2024Article
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- Divergent projections from locus coeruleus to the corticobasal ganglia system and ventral tegmental area of the adult male zebra finch.The Journal of comparative neurology · 2023Article
- Striatal Injury Induces Overall Brain Alteration at the Pallial, Thalamic, and Cerebellar Levels.Biology · 2022Article
- Performance-Dependent Consolidation of Learned Vocal Changes in Adult Songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Intrinsic motivation for singing in songbirds is enhanced by temporary singing suppression and regulated by dopamine.Scientific reports · 2021Article
- Plasticity of stereotyped birdsong driven by chronic manipulation of cortical-basal ganglia activity.Current biology : CB · 2021Article
- Expression of FoxP2 in the basal ganglia regulates vocal motor sequences in the adult songbird.Nature communications · 2021Article
- Variable but not random: temporal pattern coding in a songbird brain area necessary for song modification.Journal of neurophysiology · 2021Article
- Long-term Devocalization of Zebra Finches.Bio-protocol · 2020Article
- Corticobasal ganglia projecting neurons are required for juvenile vocal learning but not for adult vocal plasticity in songbirds.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sensory feedback independent pre-song vocalizations correlate with time to song initiation.The Journal of experimental biology · 2019Article
- The Avian Basal Ganglia Are a Source of Rapid Behavioral Variation That Enables Vocal Motor Exploration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- An automated approach to the quantitation of vocalizations and vocal learning in the songbird.PLoS computational biology · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Basal ganglia-thalamocortical circuits are critical for motor control and motor learning. Classically, basal ganglia nuclei are thought to regulate motor behavior by increasing or decreasing cortical firing rates, and basal ganglia diseases are assumed to reflect abnormal overall activity levels. More recent studies suggest instead that motor disorders derive from abnormal firing patterns, and have led to the hypothesis that surgical treatments, such as pallidotomy, act primarily by eliminating pathological firing patterns. Surprisingly little is known, however, about how the basal ganglia normally influence task-related cortical activity to regulate motor behavior, and how lesions of the basal ganglia influence cortical firing properties. Here, we investigated these questions in a songbird circuit that has striking homologies to mammalian basal ganglia-thalamocortical circuits but is specialized for singing. The "cortical" outflow nucleus of this circuit is required for song plasticity and normally exhibits increased firing during singing and song-locked burst firing. We found that lesions of the striato-pallidal nucleus in this circuit prevented hearing-dependent song changes. These basal ganglia lesions also stripped the cortical outflow neurons of their patterned burst firing during singing, without changing their spontaneous or singing-related firing rates. Taken together, these results suggest that the basal ganglia are essential not for normal cortical firing rates but for driving task-specific cortical firing patterns, including bursts. Moreover, such patterned bursting appears critical for motor plasticity. Our findings thus provide support for therapies that aim to treat basal ganglia movement disorders by normalizing firing patterns.
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