ArticleJournal of virology2013
A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression.
Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 33 citations in OpenAlex.
- Influence of dapivirine vaginal ring use on cervicovaginal immunity and functional microbiome in adolescent girls.AIDS (London, England) · 2021Trial
- Mucosal effects of tenofovir 1% gel.eLife · 2015Trial
- Article
- The role of endometrial B cells in normal endometrium and benign female reproductive pathologies: a systematic review.Human reproduction open · 2022Article
- Simian Immunodeficiency Virus Susceptibility, Immunology, and Microbiome in the Female Genital Tract of Adolescent Versus Adult Pigtail Macaques.AIDS research and human retroviruses · 2021Article
- Treatment with Commonly Used Antiretroviral Drugs Induces a Type I/III Interferon Signature in the Gut in the Absence of HIV Infection.Cell reports. Medicine · 2020Article
- Pregnancy associates with alterations to the host and microbial proteome in vaginal mucosa.American journal of reproductive immunology (New York, N.Y. : 1989) · 2020Article
- A2ML1 and otitis media: novel variants, differential expression, and relevant pathways.Human mutation · 2019Article
- A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.Molecular & cellular proteomics : MCP · 2019Article
- Intestinal damage precedes mucosal immune dysfunction in SIV infection.Mucosal immunology · 2018Article
- Article
- MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.Mucosal immunology · 2017Article
- Mucosal and Systemic γδ+ T Cells Associated with Control of Simian Immunodeficiency Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- The reproductive cycle is a pathogenic determinant during gonococcal pelvic inflammatory disease in mice.Mucosal immunology · 2016Article
- Friend or Foe: Innate Sensing of HIV in the Female Reproductive Tract.Current HIV/AIDS reports · 2016Review
- Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.Mucosal immunology · 2016Article
- Article
- Molecular Signatures of Immune Activation and Epithelial Barrier Remodeling Are Enhanced during the Luteal Phase of the Menstrual Cycle: Implications for HIV Susceptibility.Journal of virology · 2015Article
- Cataloguing of Potential HIV Susceptibility Factors during the Menstrual Cycle of Pig-Tailed Macaques by Using a Systems Biology Approach.Journal of virology · 2015Article
- Non-Cationic Proteins Are Associated with HIV Neutralizing Activity in Genital Secretions of Female Sex Workers.PloS one · 2015Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many mucosal factors in the female genital tract (FGT) have been associated with HIV susceptibility, but little is known about their anatomical distribution in the FGT compartments. This study comprehensively characterized global immune factor expression in different tissue sites of the lower and upper FGT by using a systems biology approach. Tissue sections from the ectocervix, endocervix, and endometrium from seven women who underwent hysterectomy were analyzed by a combination of quantitative mass spectrometry and immunohistochemical staining. Of the >1,000 proteins identified, 281 were found to be differentially abundant in different tissue sites. Hierarchical clustering identified four major functional pathways distinguishing compartments, including innate immune pathways (acute-phase response, LXR/RXR) and development (RhoA signaling, gluconeogenesis), which were enriched in the ectocervix/endocervix and endometrium, respectively. Immune factors important for HIV susceptibility, including antiproteases, immunoglobulins, complement components, and antimicrobial factors, were most abundant in the ectocervix/endocervix, while the endometrium had a greater abundance of certain factors that promote HIV replication. Immune factor abundance is heterogeneous throughout the FGT and shows unique immune microenvironments for HIV based on the exposure site. This may have important implications for early events in HIV transmission and site-specific susceptibility to HIV in the FGT.
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Registered trials
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