ArticleBMJ open2013
Mortality (1950-1999) and cancer incidence (1969-1999) of workers in the Port Hope cohort study exposed to a unique combination of radium, uranium and γ-ray doses.
Article in BMJ open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Radon exposure and potential health effects other than lung cancer: a systematic review and meta-analysis.Frontiers in public health · 2024Pooled it
- Exposure to low-dose radiation in occupational settings and ischaemic heart disease: a systematic review and meta-analysis.Occupational and environmental medicine · 2023Pooled it
- Deep Breaths: A Systematic Review of the Potential Effects of Employment in the Nuclear Industry on Mortality from Non-Malignant Respiratory Disease.Radiation research · 2022Pooled it
- Radon exposure and risk of cerebrovascular disease: a systematic review and meta-analysis in occupational and general population studies.Environmental science and pollution research international · 2022Pooled it
- A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure.Radiation research · 2024Review
- Third mortality follow-up of the Mallinckrodt uranium processing workers, 1942-2019.International journal of radiation biology · 2024Article
- Article
- On the choice of methodology for evaluating dose-rate effects on radiation-related cancer risks.Radiation and environmental biophysics · 2021Article
- Cohort profile: four early uranium processing facilities in the US and Canada.International journal of radiation biology · 2021Article
- Site-specific concentration of uranium in urine of workers of the hydrometallurgical plant of Stepnogorsk mining and chemical combine.Radiation and environmental biophysics · 2020Article
- Dose limits for occupational exposure to ionising radiation and genotoxic carcinogens: a German perspective.Radiation and environmental biophysics · 2020Review
- Risk of stomach cancer incidence in a cohort of Mayak PA workers occupationally exposed to ionizing radiation.PloS one · 2020Article
- Low radon exposures and lung cancer risk: joint analysis of the Czech, French, and Beaverlodge cohorts of uranium miners.International archives of occupational and environmental health · 2019Article
- Low-dose ionizing radiation increases the mortality risk of solid cancers in nuclear industry workers: A meta-analysis.Molecular and clinical oncology · 2018Article
- First mortality analysis in the French cohort of uranium millers (F-Millers), period 1968-2013.International archives of occupational and environmental health · 2018Article
- Analysis of mortality in a pooled cohort of Canadian and German uranium processing workers with no mining experience.International archives of occupational and environmental health · 2018Article
- Cancer and non-cancer mortality among French uranium cycle workers: the TRACY cohort.BMJ open · 2016Article
- Lung cancer risk at low radon exposure rates in German uranium miners.British journal of cancer · 2015Article
- Mortality from internal and external radiation exposure in a cohort of male German uranium millers, 1946-2008.International archives of occupational and environmental health · 2015Article
- Cerebrovascular Diseases in Workers at Mayak PA: The Difference in Radiation Risk between Incidence and Mortality.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesUranium processing workers are exposed to uranium and radium compounds from the ore dust and to γ-ray radiation, but less to radon decay products (RDP), typical of the uranium miners. We examined the risks of these exposures in a cohort of workers from Port Hope radium and uranium refinery and processing plant.
designA retrospective cohort study with carefully documented exposures, which allowed separation of those with primary exposures to radium and uranium. SETTINGS: Port Hope, Ontario, Canada, uranium processors with no mining experience.
participants3000 male and female workers first employed (1932-1980) and followed for mortality (1950-1999) and cancer incidence (1969-1999). OUTCOME MEASURES: Cohort mortality and incidence were compared with the general Canadian population. Poisson regression was used to evaluate the association between cumulative RDP exposures and γ-ray doses and causes of death and cancers potentially related to radium and uranium processing.
resultsOverall, workers had lower mortality and cancer incidence compared with the general Canadian population. In analyses restricted to men (n=2645), the person-year weighted mean cumulative RDP exposure was 15.9 working level months (WLM) and the mean cumulative whole-body γ-ray dose was 134.4 millisieverts. We observed small, non-statistically significant increases in radiation risks of mortality and incidence of lung cancer due to RDP exposures (excess relative risks/100 WLM=0.21, 95% CI <-0.45 to 1.59 and 0.77, 95% CI <-0.19 to 3.39, respectively), with similar risks for those exposed to radium and uranium. All other causes of death and cancer incidence were not significantly associated with RDP exposures or γ-ray doses or a combination of both.
conclusionsIn one of the largest cohort studies of workers exposed to radium, uranium and γ-ray doses, no significant radiation-associated risks were observed for any cancer site or cause of death. Continued follow-up and pooling with other cohorts of workers exposed to by-products of radium and uranium processing could provide valuable insight into occupational risks and suspected differences in risk with uranium miners.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.