ReviewAIDS reviews
Effects of political conflict-induced treatment interruptions on HIV drug resistance.
Review in AIDS reviews. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- State of HIV research in Venezuela: a systematic review.BMC infectious diseases · 2025Pooled it
- Oral health system strengthening in fragile and conflict-affected states: A systematic review.Journal of global health · 2024Pooled it
- HIV/AIDS in Conflict-Affected Countries, 2024-2025.Journal of epidemiology and global health · 2026Article
- Challenges Faced by Perinatally-Infected Kenyan Adolescents and Youth Living with HIV During the COVID-19 Pandemic.AIDS and behavior · 2025Article
- Continuity of care during severe civil unrest with a model of community-based HIV care: a retrospective cohort study from Haiti.Lancet regional health. Americas · 2024Article
- The impact of armed conflicts on HIV treatment outcomes in Sub-Saharan Africa: a systematic review and meta-analysis.Conflict and health · 2024Review
- The Effect of Armed Conflict on Treatment Interruption, Its Outcome and Associated Factors Among Chronic Disease Patients in North East, Amhara, Ethiopia, 2022.Patient related outcome measures · 2023Article
- Article
- Early-career research education mentoring: a successful program in NeuroHIV and mental health (TRNAMH).NeuroImmune pharmacology and therapeutics · 2023Article
- Left behind on the path to 90-90-90: understanding and responding to HIV among displaced people.Journal of the International AIDS Society · 2022Article
- Economic, Mental Health, HIV Prevention and HIV Treatment Impacts of COVID-19 and the COVID-19 Response on a Global Sample of Cisgender Gay Men and Other Men Who Have Sex with Men.AIDS and behavior · 2021Article
- Social, economic, and health effects of the COVID-19 pandemic on adolescents retained in or recently disengaged from HIV care in Kenya.PloS one · 2021Article
- Beyond dose: Pulsed antibiotic treatment schedules can maintain individual benefit while reducing resistance.Scientific reports · 2018Article
- Article
- Simultaneous Detection of Major Drug Resistance Mutations of HIV-1 Subtype B Viruses from Dried Blood Spot Specimens by Multiplex Allele-Specific Assay.Journal of clinical microbiology · 2016Article
- Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: a narrative review.Journal of the International AIDS Society · 2015Review
- Stock-outs of essential health products in Mozambique - longitudinal analyses from 2011 to 2013.Tropical medicine & international health : TM & IH · 2014Article
- Research components of the Brown Kenya Program: a personal and professional perspective.Rhode Island medical journal (2013) · 2013Article
- Antiretroviral treatment interruptions induced by the Kenyan postelection crisis are associated with virological failure.Journal of acquired immune deficiency syndromes (1999) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Thirty-four million people worldwide were living with the HIV by the end of 2010. Despite significant advances in antiretroviral therapy, drug resistance remains a major deterrent to successful, enduring treatment. Unplanned interruptions in antiretroviral therapy have negative effects on HIV treatment outcomes, including increased morbidity and mortality, as well as development of drug resistance. Treatment interruptions due to political conflicts, not infrequent in resource-limited settings, result in disruptions in health care, infrastructure, or treatment facilities and patient displacement. Such circumstances are ideal bases for antiretroviral therapy resistance development, but there is limited awareness of and data available on the association between political conflict and the development of HIV drug resistance. In this review we identify and discuss this association and review how varying antiretroviral therapy half-lives, genetic barriers, different HIV subtypes, and archived resistance can lead to lack of medication effectiveness upon post-conflict resumption of care. Optimized antiretroviral therapy stopping strategies as well as infrastructural concerns and stable HIV treatment systems to ensure continuity of care and rapid resumption of care must be addressed in order to mitigate risks of HIV drug resistance development during and after political conflicts. Increased awareness of such associations by clinicians as well as politicians and stakeholders is essential.
Indexed as
Identifiers
23449225PMC3774601What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.