ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2013
COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Risky decision-making in individuals with substance use disorder: A meta-analysis and meta-regression review.Psychopharmacology · 2020Pooled it
- Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Cannabis Use and Academic Performance in College Students: The Role of Procrastination.Cannabis (Albuquerque, N.M.) · 2024Article
- Supporting Machine Learning Model in the Treatment of Chronic Pain.Biomedicines · 2023Article
- Cannabis Pharmacogenomics: A Path to Personalized Medicine.Current issues in molecular biology · 2023Review
- Cannabinoids and Multiple Sclerosis: A Critical Analysis of Therapeutic Potentials and Safety Concerns.Pharmaceutics · 2023Review
- Regular recreational Cannabis users exhibit altered neural oscillatory dynamics during attention reorientation.Psychological medicine · 2023Article
- Which came first: Cannabis use or deficits in impulse control?Progress in neuro-psychopharmacology & biological psychiatry · 2021Review
- Decision Making and Impulsivity in Young Adult Cannabis Users.Frontiers in psychology · 2021Article
- Cognition and addiction .Dialogues in clinical neuroscience · 2019Review
- Association of GDNF and CNTNAP2 gene variants with gambling.Journal of behavioral addictions · 2019Article
- Sequential exploration in the Iowa gambling task: Validation of a new computational model in a large dataset of young and old healthy participants.PLoS computational biology · 2019Article
- Pharmacogenetics of Cannabinoids.European journal of drug metabolism and pharmacokinetics · 2018Review
- VNTR-DAT1 and COMTVal158Met Genotypes Modulate Mental Flexibility and Adaptive Behavior Skills in Down Syndrome.Frontiers in behavioral neuroscience · 2016Article
- Interaction Between Functional Genetic Variation of DRD2 and Cannabis Use on Risk of Psychosis.Schizophrenia bulletin · 2015Article
- Functional genetic variation of the cannabinoid receptor 1 and cannabis use interact on prefrontal connectivity and related working memory behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Article
- Maladaptive decision making and substance use outcomes in high-risk individuals: preliminary evidence for the role of 5-HTTLPR variation.Journal of studies on alcohol and drugs · 2014Article
- Cannabis use and neurocognitive functioning in a non-clinical sample of users.Addictive behaviors · 2014Article
- Dexmedetomidine decreases requirement of thiopentone sodium and pentazocine followed with improved recovery in patients undergoing laparoscopic cholecystectomy.Journal of anaesthesiology, clinical pharmacology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
The adverse effects of cannabis use on executive functions are still controversial, fostering the need for novel biomarkers able to unveil individual differences in the cognitive impact of cannabis consumption. Two common genetic polymorphisms have been linked to the neuroadaptive impact of Δ9-tetrahydrocannabinol (THC) exposure and to executive functions in animals: the catechol-O-methyltransferase (COMT) gene val158met polymorphism and the SLC6A4 gene 5-HTTLPR polymorphism. We aimed to test if these polymorphisms moderate the harmful effects of cannabis use on executive function in young cannabis users. We recruited 144 participants: 86 cannabis users and 58 non-drug user controls. Both groups were genotyped and matched for genetic makeup, sex, age, education, and IQ. We used a computerized neuropsychological battery to assess different aspects of executive functions: sustained attention (CANTAB Rapid Visual Information Processing Test, RVIP), working memory (N-back), monitoring/shifting (CANTAB ID/ED set shifting), planning (CANTAB Stockings of Cambridge, SOC), and decision-making (Iowa Gambling Task, IGT). We used general linear model-based analyses to test performance differences between cannabis users and controls as a function of genotypes. We found that: (i) daily cannabis use is not associated with executive function deficits; and (ii) COMT val158met and 5-HTTLPR polymorphisms moderate the link between cannabis use and executive performance. Cannabis users carrying the COMT val/val genotype exhibited lower accuracy of sustained attention, associated with a more strict response bias, than val/val non-users. Cannabis users carrying the COMT val allele also committed more monitoring/shifting errors than cannabis users carrying the met/met genotype. Finally, cannabis users carrying the 5-HTTLPR s/s genotype had worse IGT performance than s/s non-users. COMT and SLC6A4 genes moderate the impact of cannabis use on executive functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.