Evidence map›Paper›PMID 23449144›Full record

ArticleNature cell biology2013

Endocytosis regulates VEGF signalling during angiogenesis.

Konstantin Gaengel, Christer Betsholtz

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. The role of syntaxins in retinal function and health.Frontiers in cellular neuroscience · 2024
    Review
  4. Imaging nanoscale axial dynamics at the basal plasma membrane.The international journal of biochemistry & cell biology · 2023
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Konstantin GaengelDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden.
Christer Betsholtz
Karolinska Institutet · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocytosis has proved to be a versatile mechanism regulating diverse cellular processes, ranging from nutrient uptake to intracellular signal transduction. New work reinforces the importance of endocytosis for VEGF receptor signalling and angiogenesis in the developing eye, and describes a mechanism for its differential regulation in angiogenic versus quiescent endothelial cells.

Indexed as

Neovascularization, PhysiologicAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAnimalsApoptosis Regulatory ProteinsCell Adhesion MoleculesCell Cycle ProteinsEndocytosisEndothelium, VascularEphrin-B2FemaleHumansMaleProtein Kinase CReceptors, Vascular Endothelial Growth FactorAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportApoptosis Regulatory ProteinsCell Adhesion MoleculesCell Cycle ProteinsDab2 protein, mouseEphrin-B2Pard3 protein, mousePKC-3 proteinProtein Kinase CReceptors, Vascular Endothelial Growth Factor

Identifiers

PMID23449144
OpenAlexW1964219517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.