ArticleThe Journal of infectious diseases2013
Mannose-binding lectin and susceptibility to schistosomiasis.
Article in The Journal of infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 39 citations in OpenAlex.
- Role of CD4+ T cell mannose binding lectin in Schistosoma-induced pulmonary hypertension.JCI insight · 2026Article
- C-type lectin receptor signaling in schistosomiasis.Frontiers in immunology · 2026Review
- Quantitative proteomics reveals significant variation in host responses of cattle with differing buffalo fly susceptibility.Frontiers in immunology · 2024Article
- Proteomics Investigations of Potential Protein Biomarkers in Sera of Rabbits Infected WithFrontiers in cellular and infection microbiology · 2021Article
- Complement protein levels and MBL2 polymorphisms are associated with dengue and disease severity.Scientific reports · 2020Article
- Collectins: Innate Immune Pattern Recognition Molecules.Advances in experimental medicine and biology · 2020Review
- Genetic and Phenotypic Screening of Mannose-Binding Lectin in Relation to Risk of Recurrent Vulvovaginal Infections in Women of North India: A Prospective Cohort Study.Frontiers in microbiology · 2017Article
- HIV-1 Disease Progression and Survival in an Adult Population in Zimbabwe: Is There an Effect of the Mannose Binding Lectin Deficiency?Omics : a journal of integrative biology · 2015Article
- Opisthorchiasis: an overlooked danger.PLoS neglected tropical diseases · 2015Article
- Lectin complement protein Collectin 11 (CL-K1) and susceptibility to urinary schistosomiasis.PLoS neglected tropical diseases · 2015Article
- Role of mannose-binding lectin deficiency in HIV-1 and schistosoma infections in a rural adult population in Zimbabwe.PloS one · 2015Article
- MBL2 variations and malaria susceptibility in Indian populations.Infection and immunity · 2014Article
- Mannose binding lectin and susceptibility to rheumatoid arthritis in Brazilian patients and their relatives.PloS one · 2014Article
- MAPKAP1 rs10118570 polymorphism is associated with anti-infection and anti-hepatic fibrogenesis in schistosomiasis japonica.PloS one · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistosomiasis.
methodsWe used the Nigerian cohort from our recently published study, which included 163 Schistosoma haematobium-infected individuals and 183 matched healthy subjects, and investigated whether MBL deficiency and MBL2 polymorphisms are associated with schistosomiasis.
resultsMBL serum levels were significantly higher in controls and were associated with protection (P < .0001). The -550H minor allele was significantly associated with protection (P = .03), and the heterozygous genotypes -550HL were observed to confer protection (P = .03). The MBL2*HYPA haplotype was significantly associated with protection (P = .03), with significantly higher serum MBL levels in controls (P = .00073). The heterozygous 6-bp deletion in the promoter was observed to be a susceptibility factor in schistosomiasis (P = .03).
conclusionsIn agreement with findings from our recently published study, the findings reported here support the observation that MBL is also associated with protection in schistosomiasis.
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