ArticleGenetics in medicine : official journal of the American College of Medical Genetics2013
Managing incidental genomic findings: legal obligations of clinicians.
Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is there a duty to recontact in light of new genetic technologies? A systematic review of the literature.Genetics in medicine : official journal of the American College of Medical Genetics · 2015Pooled it
- Legal Challenges in Precision Medicine: What Duties Arising From Genetic and Genomic Testing Does a Physician Owe to Patients?Frontiers in medicine · 2021Article
- GENETIC DUTIES.William and Mary law review · 2020Article
- Improving Incidental Finding Documentation in Trauma Patients Amidst Poor Access to Follow-up Care.The Journal of surgical research · 2020Article
- Return of Results in Participant-Driven Research: Learning from Transformative Research Models.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2020Article
- From Genetics to Genomics: Facing the Liability Implications in Clinical Care.The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics · 2020Article
- Eye Movements in Medical Image Perception: A Selective Review of Past, Present and Future.Vision (Basel, Switzerland) · 2019Review
- The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results.American journal of human genetics · 2019Article
- Discussing molecular testing in oncology care: Comparing patient and physician information preferences.Cancer · 2017Article
- Physicians' duty to recontact and update genetic advice.Personalized medicine · 2017Article
- Research participant interest in primary, secondary, and incidental genomic findings.Genetics in medicine : official journal of the American College of Medical Genetics · 2016Article
- Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine.American journal of human genetics · 2016Article
- Incidental findings of uncertain significance: To know or not to know--that is not the question.BMC medical ethics · 2016Article
- WHATIF: An open-source desktop application for extraction and management of the incidental findings from next-generation sequencing variant data.Computers in biology and medicine · 2016Article
- Management of Incidental Findings in the Era of Next-generation Sequencing.Current genomics · 2015Article
- Living laboratory: whole-genome sequencing as a learning healthcare enterprise.Clinical genetics · 2015Review
- Pragmatic and Ethical Challenges of Incorporating the Genome into the Electronic Medical Record.Current genetic medicine reports · 2014Article
- Three clinical experiences with SNP array results consistent with parental incest: a narrative with lessons learned.Journal of genetic counseling · 2014Article
- Patient decisions for disclosure of secondary findings among the first 200 individuals undergoing clinical diagnostic exome sequencing.Genetics in medicine : official journal of the American College of Medical Genetics · 2014Article
- Can I be sued for that? Liability risk and the disclosure of clinically significant genetic research findings.Genome research · 2014Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeClinical whole-exome and whole-genome sequencing will result in a broad range of incidental findings, but clinicians' obligations to identify and disclose such findings are a matter of debate. We sought legal cases that could offer insights into clinicians' legal liability.
methodsWe searched for cases in which incidental findings were related to the cause of action, using the search engines WestLaw, WestLaw Next, Lexis, and Lexis Advance.
resultsWe found no case law related to incidental findings from genetic testing but identified eight cases involving incidental findings in medical imaging. These cases suggest that clinicians may face liability for failing to disclose incidental findings that would have offered an opportunity for interventions to improve health outcome, if under the applicable standard of care, they fail to identify or appreciate the significance of the incidental finding or they negligently fail to notify other clinicians and/or the patient of the identified incidental finding. Other cases support liability for failure to refer appropriately to a clinician with greater expertise.
conclusionsClinicians may face liability if they fail to disclose incidental information that could inform interventions to improve health outcome; information lacking clinical actionability is likely to have less import.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.