ArticleJournal of anatomy2013
A new scenario of the evolutionary derivation of the mammalian diaphragm from shoulder muscles.
Article in Journal of anatomy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Osteoarthritis as an evolutionary legacy: Biological ageing and chondrocyte hypertrophy.Osteoarthritis and cartilage open · 2025Review
- Multiple embryonic sources converge to form the pectoral girdle skeleton in zebrafish.Nature communications · 2024Article
- Article
- Breaking the constraint on the number of cervical vertebrae in mammals: On homeotic transformations in lorises and pottos.Evolution & development · 2022Article
- Fibroblast-derivedeLife · 2022Article
- The earliest segmental sternum in a Permian synapsid and its implications for the evolution of mammalian locomotion and ventilation.Scientific reports · 2022Review
- Regulation of posterior Hox genes by sex steroids explains vertebral variation in inbred mouse strains.Journal of anatomy · 2022Review
- Metabolomic Profiling of Respiratory Muscles and Lung in Response to Long-Term Controlled Mechanical Ventilation.Frontiers in cell and developmental biology · 2022Article
- Novel concept for the epaxial/hypaxial boundary based on neuronal development.Journal of anatomy · 2020Article
- Regionalization of the axial skeleton predates functional adaptation in the forerunners of mammals.Nature ecology & evolution · 2020Article
- Muscles of Breathing: Development, Function, and Patterns of Activation.Comprehensive Physiology · 2019Review
- Connecting muscle development, birth defects, and evolution: An essential role for muscle connective tissue.Current topics in developmental biology · 2019Review
- Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle.Developmental biology · 2018Article
- Evolution of the muscular system in tetrapod limbs.Zoological letters · 2018Review
- Evolutionary changes of Hox genes and relevant regulatory factors provide novel insights into mammalian morphological modifications.Integrative zoology · 2018Article
- Musculoskeletal networks reveal topological disparity in mammalian neck evolution.BMC evolutionary biology · 2017Article
- Correlation betweenZoological letters · 2017Article
- Testing the evolutionary conservation of vocal motoneurons in vertebrates.Respiratory physiology & neurobiology · 2016Article
- Expansion of the neck reconstituted the shoulder-diaphragm in amniote evolution.Development, growth & differentiation · 2016Article
- Tetrapod axial evolution and developmental constraints; Empirical underpinning by a mouse model.Mechanisms of development · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The evolutionary origin of the diaphragm remains unclear, due to the lack of a comparable structure in other extant taxa. However, recent researches into the developmental mechanism of this structure have yielded new insights into its origin. Here we summarize current understanding regarding the development of the diaphragm, and present a possible scenario for the evolutionary acquisition of this uniquely mammalian structure. Recent developmental analyses indicate that the diaphragm and forelimb muscles are derived from a shared cell population during embryonic development. Therefore, the embryonic positions of forelimb muscle progenitors, which correspond to the position of the brachial plexus, likely played an important role in the evolution of the diaphragm. We surveyed the literature to reexamine the position of the brachial plexus among living amniotes and confirmed that the cervico-thoracic transition in ribs reflects the brachial plexus position. Using this osteological correlate, we concluded that the anterior borders of the brachial plexuses in the stem synapsids were positioned at the level of the fourth spinal nerve, suggesting that the forelimb buds were laid in close proximity of the infrahyoid muscles. The topology of the phrenic and suprascapular nerves of mammals is similar to that of subscapular and supracoracoid nerves, respectively, of the other amniotes, suggesting that the diaphragm evolved from a muscle positioned medial to the pectoral girdle (cf. subscapular muscle). We hypothesize that the diaphragm was acquired in two steps: first, forelimb muscle cells were incorporated into tissues to form a primitive diaphragm in the stem synapsid grade, and second, the diaphragm in cynodonts became entrapped in the region controlled by pulmonary development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.