Trial reportJournal of cell science2013
The epithelial sodium channel mediates the directionality of galvanotaxis in human keratinocytes.
Trial report in Journal of cell science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 70 citations in OpenAlex.
- Review
- Electrical stimulation: a novel adjunct therapy for diabetic foot ulcers.Frontiers in clinical diabetes and healthcare · 2025Review
- A 30-Min Exposure on Permethrin and Deltamethrin Modifies Ion Transport Pathways in the Skin.Biomolecules · 2024Article
- Cell shape and orientation control galvanotactic accuracy.Soft matter · 2024Article
- Chitosan-Glycolic Acid Gel Modification of Chloride Ion Transport in Mammalian Skin: An In Vitro Study.Molecules (Basel, Switzerland) · 2023Article
- Electrotaxis evokes directional separation of co-cultured keratinocytes and fibroblasts.Scientific reports · 2023Article
- The Impact of Diclofenac Gel on Ion Transport in the Rabbit (Molecules (Basel, Switzerland) · 2023Article
- Epithelial sodium channels in macrophage migration and polarization: role of proinflammatory cytokines TNFα and IFNγ.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Bioelectric Signaling: Role of Bioelectricity in Directional Cell Migration in Wound Healing.Cold Spring Harbor perspectives in biology · 2022Review
- A machine learning based model accurately predicts cellular response to electric fields in multiple cell types.Scientific reports · 2022Article
- Intergenerational effects of manipulating DNA methylation in the early life of an iconic invader.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Article
- The epithelial sodium channel has a role in breast cancer cell proliferation.Breast cancer research and treatment · 2021Article
- The influence of hydration status on ion transport in the rabbit (Oryctolagus cuniculus) skin-An in vitro study.PloS one · 2021Article
- Article
- Impact of Na+ permeation on collective migration of pulmonary arterial endothelial cells.PloS one · 2021Article
- Migration of Human Renal Tubular Epithelial Cells in Response to Physiological Electric Signals.Frontiers in cell and developmental biology · 2021Article
- Analysis of changes in sodium and chloride ion transport in the skin.Scientific reports · 2020Article
- Electroceutical Management of Bacterial Biofilms and Surgical Infection.Antioxidants & redox signaling · 2020Article
- Voltage-gated ion channels mediate the electrotaxis of glioblastoma cells in a hybrid PMMA/PDMS microdevice.APL bioengineering · 2020Article
- Cellular processes involved in lung cancer cells exposed to direct current electric field.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Cellular directional migration in an electric field (galvanotaxis) is one of the mechanisms guiding cell movement in embryogenesis and in skin epidermal repair. The epithelial sodium channel (ENaC), in addition to its function of regulating sodium transport in kidney, has recently been found to modulate cell locomotory speed. Here we tested whether ENaC has an additional function of mediating the directional migration of galvanotaxis in keratinocytes. Genetic depletion of ENaC completely blocks only galvanotaxis and does not decrease migration speed. Overexpression of ENaC is sufficient to drive galvanotaxis in otherwise unresponsive cells. Pharmacologic blockade or maintenance of the open state of ENaC also decreases or increases, respectively, galvanotaxis, suggesting that the channel open state is responsible for the response. Stable lamellipodial extensions formed at the cathodal sides of wild-type cells at the start of galvanotaxis; these were absent in the ENaC knockout keratinocytes, suggesting that ENaC mediates galvanotaxis by generating stable lamellipodia that steer cell migration. We provide evidence that ENaC is required for directional migration of keratinocytes in an electric field, supporting a role for ENaC in skin wound healing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.