ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Layer-specific experience-dependent rewiring of thalamocortical circuits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Inhibitory Gating of Thalamocortical Inputs onto Rat Gustatory Insular Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- β-Catenin and SOX2 Interaction Regulate Visual Experience-Dependent Cell Homeostasis in the DevelopingInternational journal of molecular sciences · 2023Article
- Altered Thalamocortical Signaling in a Mouse Model of Parkinson's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- A circuit mechanism for independent modulation of excitatory and inhibitory firing rates after sensory deprivation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Metastable dynamics of neural circuits and networks.Applied physics reviews · 2022Review
- The Role of Inhibitory Interneurons in Circuit Assembly and Refinement Across Sensory Cortices.Frontiers in neural circuits · 2022Review
- Article
- Presynaptic GABAA Receptors Modulate Thalamocortical Inputs in Layer 4 of Rat V1.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Article
- Optogenetic rewiring of thalamocortical circuits to restore function in the stroke injured brain.Nature communications · 2017Article
- Neurophysiology and Regulation of the Balance Between Excitation and Inhibition in Neocortical Circuits.Biological psychiatry · 2017Review
- Article
- Posterior Thalamic Nucleus Modulation of Tactile Stimuli Processing in Rat Motor and Primary Somatosensory Cortices.Frontiers in neural circuits · 2017Article
- Laminar- and Target-Specific Amygdalar Inputs in Rat Primary Gustatory Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Unbiased, High-Throughput Electron Microscopy Analysis of Experience-Dependent Synaptic Changes in the Neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Article
- Experience-Dependent, Layer-Specific Development of Divergent Thalamocortical Connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Adult cortical plasticity following injury: Recapitulation of critical period mechanisms?Neuroscience · 2014Review
- Developmental self-construction and -configuration of functional neocortical neuronal networks.PLoS computational biology · 2014Article
- Target-specific properties of thalamocortical synapses onto layer 4 of mouse primary visual cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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5 authors.
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Abstract
Thalamocortical circuits are central to sensory and cognitive processing. Recent work suggests that the thalamocortical inputs onto L4 and L6, the main input layers of neocortex, are activated differently by visual stimulation. Whether these differences depend on layer-specific organization of thalamocortical circuits; or on specific properties of synapses onto receiving neurons is unknown. Here we combined optogenetic stimulation of afferents from the visual thalamus and paired recording electrophysiology in L4 and L6 of rat primary visual cortex to determine the organization and plasticity of thalamocortical synapses. We show that thalamocortical inputs onto L4 and L6 differ in synaptic dynamics and sensitivity to visual drive. We also demonstrate that the two layers differ in the organization of thalamocortical and recurrent intracortical connectivity. In L4, a significantly larger proportion of excitatory neurons responded to light activation of thalamocortical terminal fields than in L6. The local microcircuit in L4 showed a higher degree of recurrent connectivity between excitatory neurons than the microcircuit in L6. In addition, L4 recurrently connected neurons were driven by thalamocortical inputs of similar magnitude indicating the presence of local subnetworks that may be activated by the same axonal projection. Finally, brief manipulation of visual drive reduced the amplitude of light-evoked thalamocortical synaptic currents selectively onto L4. These data are the first direct indication that thalamocortical circuits onto L4 and L6 support different aspects of cortical function through layer-specific synaptic organization and plasticity.
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