ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Basolateral amygdala lesions facilitate reward choices after negative feedback in rats.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Contribution of amygdala to dynamic model arbitration under uncertainty.Nature communications · 2025Article
- Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex.Nature communications · 2025Article
- Effects of chronic stress on cognitive function - From neurobiology to intervention.Neurobiology of stress · 2024Review
- Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Models of KPTN-related disorder implicate mTOR signalling in cognitive and overgrowth phenotypes.Brain : a journal of neurology · 2023Article
- Medial orbitofrontal cortical regulation of different aspects of Pavlovian and instrumental reward seeking.Psychopharmacology · 2023Article
- Theta oscillations in anterior cingulate cortex and orbitofrontal cortex differentially modulate accuracy and speed in flexible reward learning.Oxford open neuroscience · 2023Article
- Review
- Reinforcement learning detuned in addiction: integrative and translational approaches.Trends in neurosciences · 2022Review
- Foraging with the frontal cortex: A cross-species evaluation of reward-guided behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Sustained MK-801 induced deficit in a novel probabilistic reversal learning task.Frontiers in pharmacology · 2022Article
- Unique features of stimulus-based probabilistic reversal learning.Behavioral neuroscience · 2021Article
- A bidirectional corticoamygdala circuit for the encoding and retrieval of detailed reward memories.eLife · 2021Article
- Organization of Afferents along the Anterior-posterior and Medial-lateral Axes of the Rat Orbitofrontal Cortex.Neuroscience · 2021Article
- Dissociable and Paradoxical Roles of Rat Medial and Lateral Orbitofrontal Cortex in Visual Serial Reversal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- The basolateral amygdala-medial prefrontal cortex circuitry regulates behavioral flexibility during appetitive reversal learning.Behavioral neuroscience · 2020Article
- Contributions of anterior cingulate cortex and basolateral amygdala to decision confidence and learning under uncertainty.Nature communications · 2019Article
- Article
- Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.eLife · 2019Article
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9 authors.
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Abstract
The orbitofrontal cortex (OFC) and basolateral amygdala (BLA) constitute part of a neural circuit important for adaptive, goal-directed learning. One task measuring flexibility of response to changes in reward is discrimination reversal learning. Damage to OFC produces well documented impairments on various forms of reversal learning in rodents, monkeys, and humans. Recent reports show that BLA, though highly interconnected with OFC, may be differentially involved in reversal learning. In the present experiment, we compared the effects of bilateral, ibotenic acid lesions of OFC or BLA (or SHAM) on visual discrimination and reversal learning. Specifically, we used pairwise visual discrimination methods, as is commonly administered in non-human primate studies, and analyzed how animals use positive and negative trial-by-trial feedback, domains not previously explored in a rat study. As expected, OFC lesions displayed significantly slower reversal learning than SHAM and BLA rats across sessions. Rats with BLA lesions, conversely, showed facilitated reversal learning relative to SHAM and OFC groups. Furthermore, a trial-by-trial analysis of the errors committed showed the BLA group benefited more from incorrectly performed trials (or negative feedback) on future choices than either SHAM or OFC rats. This provides evidence that BLA and OFC are involved in updating responses to changes in reward contingency and that the roles are distinct. Our results are discussed in relation to a competitive framework model for OFC and BLA in reward processing.
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